Article: Species differences in susceptibilities of Proteeae spp. to six cephalosporins and three aminoglycosides

Six cephalosporins and three aminoglycosides were examined for activity against 1,693 isolates belonging to six species of Proteeae. The most notable species-specific differences included the marked susceptibility of Providencia alcalifaciens and Proteus mirabilis to cephalothin, the resistance of Proteus vulgaris to cefamandole, and the resistance of Providencia stuartii to gentamicin and tobramycin. The third-generation cephalosporins cefotaxime and moxalactam were substantially more inhibitory than were cefoperazone, cefamandole, and cefoxitin. P. stuartii, generally the most resistant species, was, however, markedly susceptible to moxalactam and cefotaxime.

Citing Articles

Activities of oral antibiotics on Providencia strains isolated from institutionalized elderly patients with urinary tract infections.

Cornaglia G, Frugoni S, Mazzariol A, Piacentini E, Berlusconi A, Fontana R Antimicrob Agents Chemother. 1995; 39(12):2819-21.

PMID: 8593030 PMC: 163040. DOI: 10.1128/AAC.39.12.2819.

Comparative in vitro activity of semisynthetic penicillins against Proteeae.

Hawkey P, Pedler S, Turner A Antimicrob Agents Chemother. 1983; 23(4):619-21.

PMID: 6859841 PMC: 184713. DOI: 10.1128/AAC.23.4.619.

Susceptibilities of 45 clinical isolates of Proteus penneri.

Fuksa M, Krajden S, Lee A Antimicrob Agents Chemother. 1984; 26(3):419-20.

PMID: 6508270 PMC: 176184. DOI: 10.1128/AAC.26.3.419.

Moxalactam (latamoxef). A review of its antibacterial activity, pharmacokinetic properties and therapeutic use.

Carmine A, Brogden R, Heel R, Romankiewicz J, Speight T, Avery G Drugs. 1983; 26(4):279-333.

PMID: 6354685 DOI: 10.2165/00003495-198326040-00001.

Speciation, serotyping, antimicrobial sensitivity and plasmid content of Proteeae from the environment of calf-rearing units in South West England.

Hawkey P, Penner J, LINTON A, Hawkey C, Crisp L, Hinton M J Hyg (Lond). 1986; 97(3):405-17.

PMID: 3540110 PMC: 2082892. DOI: 10.1017/s0022172400063592.

References

1.

Penner J, Preston M . Differences among Providencia species in their in vitro susceptibilities to five antibiotics. Antimicrob Agents Chemother. 1980; 18(6):868-71. PMC: 352980. DOI: 10.1128/AAC.18.6.868. View

2.

COSENZA B, Podgwaite J . A new species of Proteus isolated from larvae of the gypsy moth Porthetria dispar (L.). Antonie Van Leeuwenhoek. 1966; 32(2):187-91. DOI: 10.1007/BF02097459. View

3.

Penner J, Hinton N, Hennessy J . Biotypes of Proteus rettgeri. J Clin Microbiol. 1975; 1(2):136-42. PMC: 274988. DOI: 10.1128/jcm.1.2.136-142.1975. View

4.

Penner J, Hinton N, Hamilton L, HENNESSY J . Three episodes of nosocomial urinary tract infections caused by one O-serotype of Providencia stuartii. J Urol. 1981; 125(5):668-71. DOI: 10.1016/s0022-5347(17)55157-5. View

5.

Overturf G, Wilkins J, Ressler R . Emergence of resistance of Providencia stuartii to multiple antibiotics: speciation and biochemical characterization of Providencia. J Infect Dis. 1974; 129(3):353-7. DOI: 10.1093/infdis/129.3.353. View

6.

Story P . Proteus infections in hospital. J Pathol Bacteriol. 1954; 68(1):55-62. DOI: 10.1002/path.1700680107. View

7.

Washington 2nd J, Senjem D, Haldorson A, Schutt A, Martin W . Nosocomially acquired bacteriuria due to Proteus rettgeri and Providencia stuartii. Am J Clin Pathol. 1973; 60(6):836-8. DOI: 10.1093/ajcp/60.6.836. View

8.

von Graevenitz A, Nourbakhsh M . Antimicrobial resistance of the genera Proteus, Providencia and Serratia with special reference to multiple resistance patterns. Med Microbiol Immunol. 1972; 157(2):142-8. DOI: 10.1007/BF02124474. View

9.

Adler J, Burke J, Martin D, FINLAND M . Proteus infections in a general hospital. II. Some clinical and epidemiological characteristis. With an analysis of 71 cases of proteus bacteremia. Ann Intern Med. 1971; 75(4):531-6. DOI: 10.7326/0003-4819-75-4-531. View

10.

POTEE K, WRIGHT S, FINLAND M . In vitro susceptibility of recently isolated strains of Proteus to ten antibiotics. J Lab Clin Med. 1954; 44(3):463-77. View

11.

Larsson P, Olling S . 0 antigen distribution and sensitivity to the bactericidal effect of normal human serum of Proteus strains from clinical specimens. Med Microbiol Immunol. 1977; 163(2):77-82. DOI: 10.1007/BF02121822. View

12.

Bhat P, Myers R, Feldman R . Providence group of organisms in the aetiology of juvenile diarrhoea. Indian J Med Res. 1971; 59(7):1010-8. View

Species Differences in Susceptibilities of Proteeae Spp. to Six Cephalosporins and Three Aminoglycosides