Pinane Thromboxane A2 Analogues Are Non-selective Prostanoid Antagonists in Rat and Human Stomach Muscle

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1982 Dec 1

PMID 6758907

Citations 4

Authors

A Bennett

G J Sanger

Affiliations

Soon will be listed here.

Abstract

1 Pinane thromboxane A2 (PTxA2) and its epi-OH isomer were studied on rat and human stomach longitudinal muscle. 2 PTxA2 (0.5 micrograms/ml) usually caused a slight contraction of rat gastric fundus. Contractions to PGE2, PGF2 alpha, PGI2 and epoxymethano analogues of PGH2 (U-46619 and U-44069) were substantially inhibited, whereas those to PGD2 and acetylcholine were only slightly reduced. 3 In human stomach, PTxA2 0.5 micrograms/ml rarely stimulated the muscle. Contractions to PGE2, PGF2 alpha and U-46619 were antagonized, with little effect on those to acetylcholine. 4 epi-PTxA2 (0.5 micrograms/ml) did not affect rat gastric tone. It was moderately potent against PGI2 on rat gastric fundus, but was less effective than PTxA2 against U-44069.

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