Stimulation of Resistance of Immunocompromised Mice by a Muramyl Dipeptide Analog

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1982 Sep 1

PMID 6752024

Citations 9

Authors

Y Osada

M Mitsuyama

K Matsumoto

T Une

T Otani

H Ogawa

K Nomoto

Affiliations

Soon will be listed here.

Abstract

L18-MDP(Ala), a synthetic derivative of muramyl dipeptide, enhanced resistance against Escherichia coli and Candida albicans infections in aged mice and younger adult mice whose defense mechanism(s) had been depressed by X-ray irradiation or by treatment with cyclophosphamide.

Citing Articles

Translation of peptidoglycan metabolites into immunotherapeutics.

Griffin M, Hespen C, Wang Y, Hang H Clin Transl Immunology. 2019; 8(12):e1095.

PMID: 31798878 PMC: 6883908. DOI: 10.1002/cti2.1095.

Stimulation of complement production in mice by N alpha-(N-acetylmuramyl-L-alanyl-D-isoglutamine)-N epsilon-stearoyl-L-lysine.

Endo N, Okuda T, Osada Y, ZEN-YOJI H Infect Immun. 1983; 42(2):618-22.

PMID: 6642645 PMC: 264473. DOI: 10.1128/iai.42.2.618-622.1983.

Stimulation of non-specific resistance to infections by synthetic immunoregulatory agents.

Parant M, CHEDID L Infection. 1984; 12(3):230-4.

PMID: 6469369 DOI: 10.1007/BF01640913.

Enhancement of host resistance against Listeria infection by Lactobacillus casei: role of macrophages.

Sato K Infect Immun. 1984; 44(2):445-51.

PMID: 6425222 PMC: 263539. DOI: 10.1128/iai.44.2.445-451.1984.

Stimulation of nonspecific resistance to infection induced by muramyl dipeptide analogs substituted in the gamma-carboxyl group and evaluation of N alpha-muramyl dipeptide-N epsilon-stearoyllysine.

Matsumoto K, Otani T, Une T, Osada Y, Ogawa H, Azuma I Infect Immun. 1983; 39(3):1029-40.

PMID: 6341226 PMC: 348060. DOI: 10.1128/iai.39.3.1029-1040.1983.

References

Collis C . Lung damage from cytotoxic drugs. Cancer Chemother Pharmacol. 1980; 4(1):17-27. DOI: 10.1007/BF00255453. View

Kireszenbaum F, FERRARESI R . Enhancement of host resistance against Trypanosoma cruzi infection by the immunoregulatory agent muramyl dipeptide. Infect Immun. 1979; 25(1):273-8. PMC: 414448. DOI: 10.1128/iai.25.1.273-278.1979. View

Krahenbuhl J, Sharma S, FERRARESI R, Remington J . Effects of muramyl dipeptide treatment on resistance to infection with Toxoplasma gondii in mice. Infect Immun. 1981; 31(2):716-22. PMC: 351369. DOI: 10.1128/iai.31.2.716-722.1981. View

Dunger D, MALPAS J, Sandland M, Stansfeld A, Freeman J . The use of four-drug combination chemotherapy (D.A.V.E.) in the treatment of advanced Wilms' tumour. Cancer Chemother Pharmacol. 1981; 5(4):211-5. DOI: 10.1007/BF00434386. View

CHEDID L, Parant M, Parant F, Audibert F, Lefrancier F, CHOAY J . Enhancement of certain biological activities of muramyl dipeptide derivatives after conjugation to a multi-poly(DL-alanine)--poly(L-lysine) carrier. Proc Natl Acad Sci U S A. 1979; 76(12):6557-61. PMC: 411905. DOI: 10.1073/pnas.76.12.6557. View

Taylor R, Smith I, Ford H, Bryant B, Casey A, Smyth J . Failure of intensive combination therapy (cyclophosphamide, adriamycin, 5-fluorouracil) to control adenocarcinoma or large-cell anaplastic carcinoma of lung. Cancer Chemother Pharmacol. 1980; 4(4):271-3. DOI: 10.1007/BF00255273. View

Matsumoto K, Ogawa H, Kusama T, NAGASE O, Sawaki N, Inage M . Stimulation of nonspecific resistance to infection induced by 6-O-acyl muramyl dipeptide analogs in mice. Infect Immun. 1981; 32(2):748-58. PMC: 351510. DOI: 10.1128/iai.32.2.748-758.1981. View

Golomb H, Hanauer S . Infectious complications associated with hairy cell leukemia. J Infect Dis. 1981; 143(5):639-43. DOI: 10.1093/infdis/143.5.639. View

Matsumoto T, Miake S, Mitsuyama M, Takeya K, Nomoto K . Augmented resistance to Listeria monocytogenes in mice at an early stage of aging. J Clin Lab Immunol. 1979; 2(1):55-8. View

10.

Cummings N, Pabst M, JOHNSTON Jr R . Activation of macrophages for enhanced release of superoxide anion and greater killing of Candida albicans by injection of muramyl dipeptide. J Exp Med. 1980; 152(6):1659-69. PMC: 2186025. DOI: 10.1084/jem.152.6.1659. View

11.

Nelson E, Becker J . The effect of whole-body x irradiation on the bactericidal activity of phagocytic cells. I. Survival of Pseudomonas aeruginosa within phagocytes from peritoneal exudates of mice. J Infect Dis. 1959; 104(1):13-9. DOI: 10.1093/infdis/104.1.13. View

12.

CHEDID L, Parant M, Parant F, Lefrancher P, CHOAY J, Lederer E . Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs. Proc Natl Acad Sci U S A. 1977; 74(5):2089-93. PMC: 431080. DOI: 10.1073/pnas.74.5.2089. View

13.

Donaldson D, MARCUS S, GYI K, PERKINS E . The influence of immunization and total body x-irradiation on intracellular digestion by peritoneal phagocytes. J Immunol. 1956; 76(3):192-9. View

14.

Fishman M, SCHECHMEISTER I . The effect of ionizing radiation on phagocytosis and the bactericidal power of the blood. II. The effect of radiation on ingestion and digestion of bacteria. J Exp Med. 1955; 101(3):275-90. PMC: 2136470. DOI: 10.1084/jem.101.3.275. View

15.

Guiot H, van der Meer J, Van Furth R . Selective antimicrobial modulation of human microbial flora: infection prevention in patients with decreased host defense mechanisms by selective elimination of potentially pathogenic bacteria. J Infect Dis. 1981; 143(5):644-54. DOI: 10.1093/infdis/143.5.644. View

16.

Buhles Jr W, Shifrine M . Adjuvant protection against bacterial infection in granulocytopenic mice. J Infect Dis. 1977; 136(1):90-5. DOI: 10.1093/infdis/136.1.90. View

17.

Osada Y, Mitsuyama M, Une T, Matsumoto K, Otani T, Satoh M . Effect of L18-MDP(Ala), a synthetic derivative of muramyl dipeptide, on nonspecific resistance of mice to microbial infections. Infect Immun. 1982; 37(1):292-300. PMC: 347526. DOI: 10.1128/iai.37.1.292-300.1982. View