Potassium Contractures and Mechanical Activation in Rat Skeletal Muscle: Effects of Multivalent Cations, Temperature and Tetracaine

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1984 Jul 1

PMID 6743916

Citations 2

Authors

R Anwyl

J D Bruton

J V McLoughlin

Affiliations

Soon will be listed here.

Abstract

The effects of cations, temperature and tetracaine on potassium-induced contractures of rat soleus and extensor digitorus longus (e.d.l.) muscles were investigated. In the soleus, the threshold for the potassium contracture was lower (10-20 vs 20-40 mM), the peak amplitude was up to fourteen times larger, and the time course was about one half that in the e.d.l. muscle. The extent of inactivation of a test potassium contracture was directly related to the concentration of potassium in the conditioning solution and the period of exposure. Removal of calcium reduced the amplitude and time course of potassium contractures in both preparations. Addition of cobalt (10 mM) reduced the amplitude but prolonged the time course of contractures. Exposure of muscles to tetracaine (10(-5)-10(-6) M for 30 min) increased, but higher concentrations reduced, the amplitude of potassium contractures. When present for one minute, tetracaine (1 mM) moved the potassium activation curve to higher, and the potassium inactivation curve to lower, potassium concentrations.

Citing Articles

External Ca(2+)-dependent excitation--contraction coupling in a population of ageing mouse skeletal muscle fibres.

Payne A, Zheng Z, Gonzalez E, Wang Z, Messi M, Delbono O J Physiol. 2004; 560(Pt 1):137-55.

PMID: 15297570 PMC: 1665204. DOI: 10.1113/jphysiol.2004.067322.

Inactivation of excitation-contraction coupling in rat extensor digitorum longus and soleus muscles.

Chua M, Dulhunty A J Gen Physiol. 1988; 91(5):737-57.

PMID: 3418320 PMC: 2216151. DOI: 10.1085/jgp.91.5.737.

References

FRANKENHAEUSER B, Lannergren J . The effect of calcium on the mechanical response of single twitch muscle fibres of Xenopus laevis. Acta Physiol Scand. 1967; 69(3):242-54. DOI: 10.1111/j.1748-1716.1967.tb03518.x. View

LUETTGAU H . THE ACTION OF CALCIUM IONS ON POTASSIUM CONTRACTURES OF SINGLE MUSCLE FIBRES. J Physiol. 1963; 168:679-97. PMC: 1359447. DOI: 10.1113/jphysiol.1963.sp007215. View

Caputo C . The effect of low temperature on the excitation-contraction coupling phenomena of frog single muscle fibres. J Physiol. 1972; 223(2):461-82. PMC: 1331458. DOI: 10.1113/jphysiol.1972.sp009858. View

Caputo C . The time course of potassium contractures of single muscle fibres. J Physiol. 1972; 223(2):483-505. PMC: 1331459. DOI: 10.1113/jphysiol.1972.sp009859. View

DArrigo J . Possible screening of surface charges on crayfish axons by polyvalent metal ions. J Physiol. 1973; 231(1):117-28. PMC: 1350440. DOI: 10.1113/jphysiol.1973.sp010223. View

CHIARANDINI D, Stefani E . Effects of manganese on the electrical and mechanical properties of frog skeletal muscle fibres. J Physiol. 1973; 232(1):129-47. PMC: 1350495. DOI: 10.1113/jphysiol.1973.sp010260. View

Caputo C . The effect of caffeine and tetracaine on the time course of potassium contractures of single muscle fibres. J Physiol. 1976; 255(1):191-207. PMC: 1309240. DOI: 10.1113/jphysiol.1976.sp011275. View

Almers W, Best P . Effects of tetracaine on displacement currents and contraction of frog skeletal muscle. J Physiol. 1976; 262(3):583-611. PMC: 1307663. DOI: 10.1113/jphysiol.1976.sp011611. View

Almers W . Differential effects of tetracaine on delayed potassium channels and displacement currents in frog skeletal muscle. J Physiol. 1976; 262(3):613-37. PMC: 1307664. DOI: 10.1113/jphysiol.1976.sp011612. View

10.

Caputo C, Fernandez de Bolanos P . Membrane potential, contractile activation and relaxation rates in voltage clamped short muscle fibres of the frog. J Physiol. 1979; 289:175-89. PMC: 1281364. DOI: 10.1113/jphysiol.1979.sp012731. View

11.

LUTTGAU H, Spiecker W . The effects of calcium deprivation upon mechanical and electrophysiological parameters in skeletal muscle fibres of the frog. J Physiol. 1979; 296:411-29. PMC: 1279086. DOI: 10.1113/jphysiol.1979.sp013013. View

12.

Foulks J, Morishita L . The temperature dependence of ionic influences on contractile function in frog twitch muscle. Can J Physiol Pharmacol. 1980; 58(1):74-84. DOI: 10.1139/y80-013. View

13.

FRANK G . The current view of the source of trigger calcium in excitation-contraction coupling in vertebrate skeletal muscle. Biochem Pharmacol. 1980; 29(18):2399-406. DOI: 10.1016/0006-2952(80)90341-x. View

14.

McDONALD T, Pelzer D, TRAUTWEIN W . Does the calcium current modulate the contraction of the accompanying beat? A study of E-C coupling in mammalian ventricular muscle using cobalt ions. Circ Res. 1981; 49(3):576-83. DOI: 10.1161/01.res.49.3.576. View

15.

. Comparison of the action of La3+ and Ca2+ on contraction threshold and other membrane parameters of frog skeletal muscle. J Membr Biol. 1981; 62(1-2):95-103. DOI: 10.1007/BF01870203. View

16.

Dulhunty A . Slow potassium contractures in mouse limb muscles. J Physiol. 1981; 314:91-105. PMC: 1249419. DOI: 10.1113/jphysiol.1981.sp013693. View

17.

Cota G, Stefani E . Effects of external calcium reduction on the kinetics of potassium contractures in frog twitch muscle fibres. J Physiol. 1981; 317:303-16. PMC: 1246790. DOI: 10.1113/jphysiol.1981.sp013826. View

18.

Cota G, Stefani E . External calcium and contractile activation during potassium contractures in twitch muscle fibres of the frog. Can J Physiol Pharmacol. 1982; 60(4):513-23. DOI: 10.1139/y82-071. View

19.

HODGKIN A, Horowicz P . Potassium contractures in single muscle fibres. J Physiol. 1960; 153:386-403. PMC: 1359755. DOI: 10.1113/jphysiol.1960.sp006541. View

20.

FRANK G . Effects of changes in extracellular calcium concentration on the potassium-induced contracture of frog's skeletal muscle. J Physiol. 1960; 151:518-38. PMC: 1363281. DOI: 10.1113/jphysiol.1960.sp006457. View