Serum Inhibitor in Systemic Lupus Erythematosus Associated with Aplastic Anemia

Overview

Journal Arch Intern Med

Specialty General Medicine

Date 1984 Jul 1

PMID 6732407

Citations 11

Authors

B J Brooks Jr

H E Broxmeyer

C F Bryan

S H Leech

Affiliations

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Abstract

Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood elements. We report a case of SLE-associated aplastic anemia in which an IgG complement-dependent antibody, obtained from the patient's disease-phase serum but not remission-phase serum, suppressed growth of granulocyte-macrophage progenitor cells from bone marrow of normal donors in vitro. Therapy with plasmapheresis and immunosuppression resulted in lasting remission.

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