Effects of Beta Interferon on Human Fibroblasts at Different Population Doubling Levels. Proliferation, Cell Volume, Thymidine Uptake, and DNA Synthesis

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1984 Jun 1

PMID 6726117

Citations 3

Authors

B R Jasny

L M Pfeffer

I Tamm

Affiliations

Soon will be listed here.

Abstract

Cellular aging had no effect on the ability of beta interferon to increase cell volume and population doubling time in 76-109 cells, a line of human skin fibroblasts. However, DNA synthesis in cells at high population doubling levels (PDL 55-70) was inhibited after 72 h of beta interferon treatment (1,000 U/ml) while no inhibition of DNA synthesis was observed in cells at middle population doubling levels (PDL 30-40).

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