Pathology of Hepatitis A Infection in the Owl Monkey (Aotus Trivirgatus)

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1984 Apr 1

PMID 6711675

Citations 5

Authors

C M Keenan

S M Lemon

J W LeDuc

G A McNamee

L N Binn

Affiliations

Soon will be listed here.

Abstract

Sequential liver biopsies of owl monkeys that had been experimentally infected with one of two strains of hepatitis A virus (HM-175 or PA-33) were examined for histopathologic alterations. Preinoculation biopsies were normal with only occasional minimal mononuclear cell infiltrates in portal tracts and hepatic lobular parenchyma. Histopathologic features that were present in biopsies taken during the period of elevated serum alanine aminotransferase activity (16-43 days after the intravenous inoculation of virus) included infiltration of predominantly mononuclear inflammatory cells into portal tracts and surrounding parenchyma, degeneration and necrosis of hepatocytes, and hypertrophy of Kupffer cells. Changes were similar in monkeys infected with either HM-175 or PA-33 virus strains. Convalescent biopsies (147-186 days after inoculation) showed resolving lesions with mild portal inflammation and occasional focal collections of inflammatory cells in the parenchyma. These histologic changes are similar to those associated with hepatitis A infection in man, chimpanzees, and several species of marmosets, and support the further use of the owl monkey as a model of human hepatitis A.

Citing Articles

Comparative Pathology of Hepatitis A Virus and Hepatitis E Virus Infection.

Cullen J, Lemon S Cold Spring Harb Perspect Med. 2018; 9(4).

PMID: 29712683 PMC: 6444697. DOI: 10.1101/cshperspect.a033456.

Nonhuman Primate Models of Hepatitis A Virus and Hepatitis E Virus Infections.

Lanford R, Walker C, Lemon S Cold Spring Harb Perspect Med. 2018; 9(2).

PMID: 29686041 PMC: 6360867. DOI: 10.1101/cshperspect.a031815.

The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis.

Lanford R, Walker C, Lemon S ILAR J. 2017; 58(2):172-189.

PMID: 29045731 PMC: 5886334. DOI: 10.1093/ilar/ilx028.

Experimental hepatitis A virus (HAV) infection in cynomolgus monkeys (Macaca fascicularis): evidence of active extrahepatic site of HAV replication.

Amado L, Marchevsky R, de Paula V, Hooper C, Freire M, Gaspar A Int J Exp Pathol. 2010; 91(1):87-97.

PMID: 20096073 PMC: 2812731. DOI: 10.1111/j.1365-2613.2009.00699.x.

Leukaemic phase of mantle zone (intermediate) lymphoma: its characterisation in 11 cases.

de Oliveira M, Jaffe E, Catovsky D J Clin Pathol. 1989; 42(9):962-72.

PMID: 2794086 PMC: 501797. DOI: 10.1136/jcp.42.9.962.

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