Determination of Trimethoprim and Sulfamethoxazole (co-trimoxazole) in Body Fluids of Man by Means of High-performance Liquid Chromatography

Overview

Journal J Chromatogr

Date 1978 Jul 1

PMID 670346

Citations 14

Authors

T B Vree

Y A Hekster

A M Baars

J E Damsma

E V Kleijin

Affiliations

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Abstract

A high-performance liquid chromatographic method for the determination of trimethoprim, sulfamethoxazole and its metabolite and a series of structurally related sulfonamides is described. The half-life time of elimination of sulfamethoxazole and its metabolite N4-acetylsulfamethoxazole is 9 h for both compounds. The renal excretion rate of sulfamethoxazole depends strongly on the urinary pH. The renal excretion rate of the metabolite N4-acetylsulfamethoxazole is not dependent on the urinary pH.

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