» Articles » PMID: 6690719

A New Oncogene, C-raf, is Located on Mouse Chromosome 6

Overview
Journal J Virol
Date 1984 Jan 1
PMID 6690719
Citations 20
Authors
Affiliations
Soon will be listed here.
Abstract

The recently described acute transforming virus 3611-MSV contains cellular sequences designated v-raf. Mouse cellular DNA contains a single-copy sequence homologous to this oncogene (c-raf), and Southern blot analysis of hamster-mouse somatic cell hybrid DNAs showed that the mouse c-raf sequence is present on chromosome 6.

Citing Articles

The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy.

Yuan J, Dong X, Yap J, Hu J J Hematol Oncol. 2020; 13(1):113.

PMID: 32807225 PMC: 7433213. DOI: 10.1186/s13045-020-00949-4.


Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy.

Degirmenci U, Wang M, Hu J Cells. 2020; 9(1).

PMID: 31941155 PMC: 7017232. DOI: 10.3390/cells9010198.


Oncogene-directed small molecule inhibitors for the treatment of cutaneous melanoma.

Eliades P, Flaherty K, Tsao H Melanoma Manag. 2018; 2(2):133-147.

PMID: 30190843 PMC: 6094676. DOI: 10.2217/mmt.15.5.


Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF.

Pfeiffer V, Gotz R, Camarero G, Heinsen H, Blum R, Rapp U PLoS One. 2018; 13(3):e0192067.

PMID: 29590115 PMC: 5873938. DOI: 10.1371/journal.pone.0192067.


Decoding the full picture of Raf1 function based on its interacting proteins.

Huang Y, Guo X, Han B, Zhang X, An S, Zhang X Oncotarget. 2017; 8(40):68329-68337.

PMID: 28978120 PMC: 5620260. DOI: 10.18632/oncotarget.19353.


References
1.
Kozak C, Lawrence J, Ruddle F . A sequential staining technique for the chromosomal analysis of the interspecific mouse/hamster and mouse/human somatic cell hybrids. Exp Cell Res. 1977; 105(1):109-17. DOI: 10.1016/0014-4827(77)90156-2. View

2.
Kozak C, Sears J, HOGGAN M . Genetic mapping of the mouse oncogenes c-Ha-ras-1 and c-fes to chromosome 7. J Virol. 1983; 47(1):217-20. PMC: 255231. DOI: 10.1128/JVI.47.1.217-220.1983. View

3.
Rapp U, Todaro C . Generation of new mouse sarcoma viruses in cell culture. Science. 1978; 201(4358):821-4. DOI: 10.1126/science.210501. View

4.
Kozak C, Rowe W . Genetic mapping of the ecotropic murine leukemia virus-inducing locus of BALB/c mouse to chromosome 5. Science. 1979; 204(4388):69-71. DOI: 10.1126/science.219475. View

5.
Breindl M, Doehmer J, Willecke K, Dausman J, Jaenisch R . Germ line integration of Moloney leukemia virus: identification of the chromosomal integration site. Proc Natl Acad Sci U S A. 1979; 76(4):1938-42. PMC: 383508. DOI: 10.1073/pnas.76.4.1938. View