Mouse and Hamster Mutants As Models for Waardenburg Syndromes in Humans

Overview

Journal J Med Genet

Specialty Genetics

Date 1990 Oct 1

PMID 2246770

Citations 13

Authors

J H Asher Jr

T B Friedman

Affiliations

Soon will be listed here.

Abstract

Four different Waardenburg syndromes have been defined based upon observed phenotypes. These syndromes are responsible for approximately 2% of subjects with profound congenital hearing loss. At present, Waardenburg syndromes have not been mapped to particular human chromosomes. One or more of the mouse mutant alleles, Ph (patch), s (piebald), Sp (splotch), and Mior (microphthalmia-Oak Ridge) and the hamster mutation Wh (anophthalmic white) may be homologous to mutations causing Waardenburg syndromes. In heterozygotes, phenotypic effects of these four mouse mutations and the hamster mutation are similar to the phenotypes produced by different Waardenburg syndrome mutations. The chromosomal locations and syntenic relationships associated with three of the four mouse mutant genes have been used to predict human chromosomal locations for Waardenburg syndromes: (1) on chromosome 2q near FN1 (fibronectin 1), (2) on chromosome 3p near the proto-oncogene RAF1 or 3q near RHO (rhodopsin), and (3) on chromosome 4p near the proto-oncogene KIT. Waardenburg syndromes show extensive intrafamilial phenotypic variability. Results of our studies with the hamster mutation Wh suggest that this variability may be explained in part by modifier genes segregating within families.

Citing Articles

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Rare Association of Waardenburg Syndrome with Minimal Change Disease.

Anvesh G, Raju S, Prasad K, Sharma A, Surendra M Indian J Nephrol. 2018; 28(3):226-228.

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Waardenburg syndrome type I: Dental phenotypes and genetic analysis of an extended family.

Solia-Nasser L, de Aquino S, Paranaiba L, Gomes A, Dos-Santos-Neto P, Coletta R Med Oral Patol Oral Cir Bucal. 2016; 21(3):e321-7.

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Functional melanocytes derived from human pluripotent stem cells engraft into pluristratified epidermis.

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