Alpha 2.0
Login Register
» Articles » PMID: 6661359

Acute Treatment of Hypertensive Crisis with Nifedipine

Overview
Journal Br J Clin Pharmacol
Specialty Pharmacology
Date 1983 Dec 1
PMID 6661359
Citations 8
Authors
F T Huysmans
H E Sluiter
T A Thien
R A Koene
Affiliations
Soon will be listed here.
Abstract

Ten patients with a hypertensive crisis and a decreased renal function were treated with 10 (n = 7) or 20 (n = 3) mg nifedipine sublingually. Blood pressure was reduced in 60 min from 211 +/- 4/134 +/- 5 to 172 +/- 6/107 +/- 6 mm Hg. The decrease of blood pressure was accompanied by a rise in heart rate from 83 +/- 6 to 98 +/- 5 beats/min. In all seven patients with an encephalopathy signs of this complication were reduced. No serious side-effects were observed.

Citing Articles

Treatment of acute severe hypertension: current and newer agents.

Varon J Drugs. 2008; 68(3):283-97.

PMID: 18257607 DOI: 10.2165/00003495-200868030-00003.

Clinical review: the management of hypertensive crises.

Varon J, Marik P Crit Care. 2003; 7(5):374-84.

PMID: 12974970 PMC: 270718. DOI: 10.1186/cc2351.

Comparative tolerability profile of hypertensive crisis treatments.

Grossman E, Ironi A, Messerli F Drug Saf. 1998; 19(2):99-122.

PMID: 9704248 DOI: 10.2165/00002018-199819020-00003.

Treatment of hypertensive emergency. Comparison of a new dosage form of the calcium antagonist nitrendipine with nifedipine capsules.

Rohr G, Reimnitz P, Blanke P Intensive Care Med. 1994; 20(4):268-71.

PMID: 8046120 DOI: 10.1007/BF01708963.

Treatment of severe hypertension and hypertensive crises with nifedipine.

Houston M West J Med. 1987; 146(6):701-4.

PMID: 3303694 PMC: 1307462.

References
1.
ROMHILT D, ESTES Jr E . A point-score system for the ECG diagnosis of left ventricular hypertrophy. Am Heart J. 1968; 75(6):752-8. DOI: 10.1016/0002-8703(68)90035-5. View
2.
Murakami M, Murakami E, Takekoshi N, Tsuchiya M, Kin T . Antihypertensive effect of (4-2'-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarbonic acid dimethylester (Nifedipine, Bay-a 1040), a new coronary dilator. Jpn Heart J. 1972; 13(2):128-35. DOI: 10.1536/ihj.13.128. View
3.
Millard R, Lathrop D, GRUPP G, Ashraf M, GRUPP I, Schwartz A . Differential cardiovascular effects of calcium channel blocking agents: potential mechanisms. Am J Cardiol. 1982; 49(3):499-506. DOI: 10.1016/s0002-9149(82)80002-7. View
4.
Low R, Takeda P, Mason D, DeMaria A . The effects of calcium channel blocking agents on cardiovascular function. Am J Cardiol. 1982; 49(3):547-53. DOI: 10.1016/s0002-9149(82)80010-6. View
5.
Bayley S, Dobbs R, Robinson B . Nifedipine in the treatment of hypertension: report of a double-blind controlled trial. Br J Clin Pharmacol. 1982; 14(4):509-12. PMC: 1427595. DOI: 10.1111/j.1365-2125.1982.tb02021.x. View