Treatment of Severe Hypertension and Hypertensive Crises with Nifedipine

Overview

Journal West J Med

Specialty General Medicine

Date 1987 Jun 1

PMID 3303694

Authors

M C Houston

Affiliations

Soon will be listed here.

Abstract

The calcium channel blocker nifedipine is an effective antihypertensive agent for the treatment of severe hypertension and hypertensive crises. It produces a prompt, predictable and consistent reduction in systemic arterial pressure with minimal adverse effects. The blood pressure reduction is inversely correlated with the pretreatment blood pressure level. Various nonparenteral administration forms-oral, sublingual, buccal and rectal-permit a versatile, noninvasive, cost-effective alternative to parenteral antihypertensive therapy and continuous hemodynamic monitoring. Blood pressure is reduced to the goal level in 98% of patients with a 10- to 20-mg dose of nifedipine. Hemodynamic changes are favorable and morbidity is uncommon.

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