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Subinhibitory Concentrations of Antibiotics Alter Fibronectin Binding to Staphylococcus Aureus

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1983 Nov 1
PMID 6660855
Citations 14
Authors
R A Proctor
P J Olbrantz
D F Mosher
Affiliations
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Abstract

Fibronectin, a high-molecular-weight glycoprotein, is found in plasma and on mammalian cell surfaces. Recent reports have suggested that bacterial-fibronectin interactions play a role in bacterial attachment to host cells. Subinhibitory concentrations of lincosamines, erythromycin, and chloramphenicol decreased fibronectin binding to Staphylococcus aureus, whereas beta-lactam antibiotics enhanced this interaction.

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