Occurrence of Saxitoxin and Other Toxins in the Liver of the Pufferfish Takifugu Pardalis

Overview

Journal Toxicon

Specialty Toxicology

Date 1983 Jan 1

PMID 6658812

Citations 8

Authors

M Kodama

T Ogata

T Noguchi

J Maruyama

K Hashimoto

Affiliations

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Abstract

Highly toxic livers of the pufferfish Takifugu pardalis were extracted with acidic ethanol. The toxins extracted were partially purified by chromatography on Bio-Gel P-2 and then Bio-Rex 70, resulting in separation into three fractions I, II and III. ratios of total mouse units per fraction were approximately 0.1:100:0.01, respectively, with tetrodotoxin (TTX) as standard. By TLC, electrophoresis and a TTX analyzer, Fr. II was identified as TTX and, unexpectedly, Fr. III as saxitoxin, while Fr. I remains unidentified.

Citing Articles

Phylogeny and Toxin Profile of Freshwater Pufferfish (Genus ) Collected from 2 Different Regions in Cambodia.

Zhu H, Yamada A, Goto Y, Horn L, Ngy L, Wada M Toxins (Basel). 2020; 12(11).

PMID: 33143288 PMC: 7694119. DOI: 10.3390/toxins12110689.

Co-Occurrence of Tetrodotoxin and Saxitoxins and Their Intra-Body Distribution in the Pufferfish .

Zhu H, Sonoyama T, Yamada M, Gao W, Tatsuno R, Takatani T Toxins (Basel). 2020; 12(7).

PMID: 32635254 PMC: 7405003. DOI: 10.3390/toxins12070436.

Semiquantitation of Paralytic Shellfish Toxins by Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry Using Relative Molar Response Factors.

Qiu J, Wright E, Thomas K, Li A, McCarron P, Beach D Toxins (Basel). 2020; 12(6).

PMID: 32560098 PMC: 7354571. DOI: 10.3390/toxins12060398.

Contrasting Toxin Selectivity between the Marine Pufferfish and the Freshwater Pufferfish .

Gao W, Kanahara Y, Yamada M, Tatsuno R, Yoshikawa H, Doi H Toxins (Basel). 2019; 11(8).

PMID: 31405182 PMC: 6722796. DOI: 10.3390/toxins11080470.

Difference in Uptake of Tetrodotoxin and Saxitoxins into Liver Tissue Slices among Pufferfish, Boxfish and Porcupinefish.

Nagashima Y, Ohta A, Yin X, Ishizaki S, Matsumoto T, Doi H Mar Drugs. 2018; 16(1).

PMID: 29316695 PMC: 5793065. DOI: 10.3390/md16010017.