Contrasting Toxin Selectivity Between the Marine Pufferfish and the Freshwater Pufferfish

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2019 Aug 14

PMID 31405182

Citations 14

Authors

Wei Gao

Yoko Kanahara

Misako Yamada

Ryohei Tatsuno

Hiroyuki Yoshikawa

Hiroyuki Doi

Tomohiro Takatani

Osamu Arakawa

Affiliations

Soon will be listed here.

Abstract

To clarify the differences in toxin selectivity between marine and freshwater pufferfish, we conducted experiments in artificially reared nontoxic specimens of (marine) and (freshwater) using tetrodotoxin (TTX) and paralytic shellfish poison (PSP; decarbamoylsaxitoxin (dcSTX) or saxitoxin (STX)). specimens were administered feed homogenate containing TTX or dcSTX (dose of toxin, 55.2 nmol/fish) and specimens were administered feed homogenate containing TTX + STX (dose of each toxin, 19.2 nmol/fish) by oral gavage. The toxin content in the intestine, muscle, skin, liver, and gonads was quantified after 24 and 48 or 72 h. In , TTX administered into the intestine was absorbed into the body and transferred and retained mainly in the skin and liver, while dcSTX was hardly retained in the body, although it partly remained in the intestine. In strong contrast, in , little TTX remained in the body, whereas STX was absorbed into the body and was transferred and retained in the ovary and skin. The findings revealed that TTX/PSP selectivity differs between the marine species and the freshwater species . , which naturally harbors TTX, selectively accumulates TTX, and , which naturally harbors PSP, selectively accumulates PSP.

Citing Articles

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