Structural Determinants of Phaseolus Vulgaris Erythroagglutinating Lectin for Oligosaccharides

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 1983 Dec 25

PMID 6654888

Citations 34

Authors

K Yamashita

A Hitoi

A Kobata

Affiliations

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Abstract

The behaviors of oligosaccharides obtained by hydrazinolysis of asparagine-linked sugar chains in an erythroagglutinating phytohemagglutinin lectin-agarose column were examined to define the structural determinants required for the interaction of asparagine-linked sugars with erythroagglutinating phytohemagglutinin. The minimal structural unit required for erythroagglutinating phytohemagglutinin binding was (formula; see text) in which R1 and R2 represent either hydrogen or sugars and R3 represents either GlcNAc leads to Asn or (Fuc alpha 1 leads to 6)GlcNAcOT.

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