Is There a Relationship Between Hypoxia, Contact Resistance, and Intercellular Communication?

Overview

Journal Radiat Environ Biophys

Specialties Biophysics
Environmental Health
Oncology
Radiology

Date 1983 Jan 1

PMID 6647756

Citations 2

Authors

H Dertinger

M Guichard

E P Malaise

Affiliations

Soon will be listed here.

Abstract

This investigation addresses the shape of radiation survival curves of cells cultured as multicell spheroids. It is shown that spheroids of cells capable of intercellular communication by gap-junctions display survival curves lacking a radioresistant fraction of hypoxic cells. Compared to the corresponding monolayers, these spheroid survival curves exhibit a uniform increase in radioresistance due to the "contact effect". In contrast, biphasic survival curves indicative of hypoxic cells are obtained with non-communicating spheroids, however, without indication of a contact effect. Evidence is presented that this relationship between intercellular communication, hypoxia, and contact effect may possibly also hold for survival curves of solid tumors.

Citing Articles

Drug and radiation resistance in spheroids: cell contact and kinetics.

Olive P, Durand R Cancer Metastasis Rev. 1994; 13(2):121-38.

PMID: 7923546 DOI: 10.1007/BF00689632.

Multicellular spheroids. A review on cellular aggregates in cancer research.

Mueller-Klieser W J Cancer Res Clin Oncol. 1987; 113(2):101-22.

PMID: 3549738 DOI: 10.1007/BF00391431.

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