Prolactin Secretion in Man: a Useful Tool to Evaluate the Activity of Drugs on Central 5-hydroxytryptaminergic Neurones. Studies with Fenfluramine

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1983 Nov 1

PMID 6639832

Citations 14

Authors

A Quattrone

G Tedeschi

U Aguglia

F Scopacasa

G F Direnzo

L Annunziato

Affiliations

Soon will be listed here.

Abstract

Acute oral administration of various doses of fenfluramine, a 5-HT releaser, induced a dose-related increase of PRL secretion in nine healthy volunteers. Fenfluramine reached the maximum effect on PRL secretion at 4 h after its administration. This effect was already significant at 2 h and lasted till 8 h. Metergoline, a 5-HT receptor blocker, when administered alone, decreased serum PRL levels in six healthy subjects. The pretreatment with this drug significantly antagonized the PRL-releasing action of fenfluramine (60 mg) suggesting that the effect of fenfluramine on PRL release may be mediated through a 5-HT mechanism in the brain. These findings suggest the possibility that serum PRL levels in humans may represent a useful tool to evaluate, in vivo, the activity of drugs possessing putative 5-hydroxytryptaminergic properties.

Citing Articles

Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.

Steinkellner T, Montgomery T, Hofmaier T, Kudlacek O, Yang J, Rickhag M J Neurosci. 2015; 35(21):8258-71.

PMID: 26019340 PMC: 4444546. DOI: 10.1523/JNEUROSCI.4034-14.2015.

Neurobiological pathways linking socioeconomic position and health.

Gianaros P, Manuck S Psychosom Med. 2010; 72(5):450-61.

PMID: 20498294 PMC: 2903752. DOI: 10.1097/PSY.0b013e3181e1a23c.

The emerging modern face of mood disorders: a didactic editorial with a detailed presentation of data and definitions.

Fountoulakis K Ann Gen Psychiatry. 2010; 9:14.

PMID: 20385020 PMC: 2865463. DOI: 10.1186/1744-859X-9-14.

Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls.

Sher L, Stanley B, Cooper T, Malone K, Mann J, Oquendo M Eur Neuropsychopharmacol. 2008; 18(9):692-9.

PMID: 18590952 PMC: 3785085. DOI: 10.1016/j.euroneuro.2008.05.005.

The UCSD Statin Study: a randomized controlled trial assessing the impact of statins on selected noncardiac outcomes.

Golomb B, Criqui M, White H, Dimsdale J Control Clin Trials. 2004; 25(2):178-202.

PMID: 15020036 PMC: 4285453. DOI: 10.1016/j.cct.2003.08.014.

References

Crosignani P, Lombroso G, Caccamo A, Reschini E, Peracchi M . Suppression of puerperal lactation by metergoline. Obstet Gynecol. 1978; 51(1):113-5. View

WIEBE R, Handwerger S, Hammond C . Failure of L-tryptophan to stimulate prolactin secretion in man. J Clin Endocrinol Metab. 1977; 45(6):1310-2. DOI: 10.1210/jcem-45-6-1310. View

Ferrari C, Caldara R, Rampini P, Telloli P, ROMUSSI M, Bertazzoni A . Inhibition of prolactin release by serotonin antagonists in hyperprolactinemic subjects. Metabolism. 1978; 27(10):1499-504. DOI: 10.1016/s0026-0495(78)80022-5. View

Quattrone A, Schettini G, Di Renzo G, Preziosi P . Pharmacological evidence of an interaction between serotonergic and dopaminergic neurons in the control of prolactin secretion in male rats. Arch Int Pharmacodyn Ther. 1979; 238(1):42-9. View

Quattrone A, Schettini G, Renzo G, Tedeschi G, Preziosi P . Effect of midbrain raphe lesion or 5,7-dihydroxytryptamine treatment on the prolactin-releasing action of quipazine and D-fenfluramine in rats. Brain Res. 1979; 174(1):71-9. DOI: 10.1016/0006-8993(79)90804-7. View

Parati E, Zanardi P, Cocchi D, Caraceni T, Muller E . Neuroendocrine effects of quipazine in man in health state or with neurological disorders. J Neural Transm. 1980; 47(4):273-97. DOI: 10.1007/BF01247322. View

Wuttke W, Bjorklund A, Baumgarten H, Lachenmayer L, Fenske M, Klemm H . De- and regeneration of brain serotonin neurons following 5,7-dihydroxytryptamine treatment: effects on serum LH, FSH and prolactin levels in male rats. Brain Res. 1977; 134(2):317-31. DOI: 10.1016/0006-8993(77)91076-9. View

Mawson C, Whittington H . Evaluation of the peripheral and central antagonistic activities against 5-hydroxytryptamine of some new agents. Br J Pharmacol. 1970; 39(1):223P-224P. PMC: 1703057. View

Sinha Y, SELBY F, Lewis U, VANDERLAAN W . A homologous radioimmunoassay for human prolactin. J Clin Endocrinol Metab. 1973; 36(3):509-16. DOI: 10.1210/jcem-36-3-509. View

10.

Lu K, Meites J . Effects of serotonin precursors and melatonin on serum prolactin release in rats. Endocrinology. 1973; 93(1):152-5. DOI: 10.1210/endo-93-1-152. View

11.

Kato Y, Nakai Y, Imura H, Chihara K, Ogo S . Effect of 5-hydroxytryptophan (5-HTP) on plasma prolactin levels in man. J Clin Endocrinol Metab. 1974; 38(4):695-7. DOI: 10.1210/jcem-38-4-695. View

12.

Smalstig E, Sawyer B, Clemens J . Inhibition of rat prolactin release by apomorphine in vivo and in vitro. Endocrinology. 1974; 95(1):123-9. DOI: 10.1210/endo-95-1-123. View

13.

Shaar C, Clemens J . The role of catecholamines in the release of anterior pituitary prolactin in vitro. Endocrinology. 1974; 95(5):1202-12. DOI: 10.1210/endo-95-5-1202. View

14.

Garattini S, Buczko W, JORI A, Samanin R . The mechanism of action of fenfluramine. Postgrad Med J. 1975; 51 Suppl 1:27-35. View

15.

Fuxe K, Farnebo L, Hamberger B, Ogren S . On the in vivo and in vitro actions of fenfluramine and its derivatives on central monoamine neurons, especially 5-hydroxytryptamine neurons, and their relation to the anorectic activity of fenfluramine. Postgrad Med J. 1975; 51 Suppl 1:35-45. View

16.

Samanin R, Bernasconi S, Quattrone A . Antinociceptive action of quipazine: relation to central serotonergic receptor stimulation. Psychopharmacologia. 1976; 46(2):219-22. DOI: 10.1007/BF00421395. View

17.

Ferrari C, PARACCHI A, Rondena M, Beck-Peccoz P, Faglia G . Effect of two serotonin antagonists on prolactin and thyrotrophin secretion in man. Clin Endocrinol (Oxf). 1976; 5(5):575-78. DOI: 10.1111/j.1365-2265.1976.tb01987.x. View

18.

Beck-Peccoz P, Ferrari C, Rondena M, PARACCHI A, Faglia G . Failure of oral 5-hydroxytryptohan administration to affect prolactin secretion in man. Horm Res. 1976; 7(4-5):303-7. DOI: 10.1159/000178741. View

19.

Langer G, SACHAR E, Gruen P, Halpern F . Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency. Nature. 1977; 266(5603):639-40. DOI: 10.1038/266639a0. View

20.

Woolf P, Lee L . Effect of the serotonin precursor, tryptophan, on pituitary hormone secretion. J Clin Endocrinol Metab. 1977; 45(1):123-33. DOI: 10.1210/jcem-45-1-123. View