Does Metergoline Selectively Attenuate 5-HT Mediated Prolactin Release?

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1991 Jan 1

PMID 1745704

Citations 2

Authors

P M Ellis

S E Gartside

C J Ware

G M Campling

P J Cowen

Affiliations

Soon will be listed here.

Abstract

Administration of the non-selective 5-HT receptor antagonist metergoline (0.5 mg/kg) to male rats attenuated the prolactin response to the 5-HT releasing agent d-fenfluramine (7.5 mg/kg) but not to the dopamine receptor antagonist haloperidol (1.5 mg/kg). In contrast, in healthy male volunteers, pretreatment with metergoline (4 mg orally) abolished the prolactin response to intravenous haloperidol (5 micrograms/kg). The findings suggest that in humans blockade of a prolactin response by a conventional oral dose of metergoline cannot be taken as evidence of involvement of 5-HT-mediated mechanisms.

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