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Generation of an HLA-restricted Cytotoxic T Cell Line Reactive Against Cultured Tumor Cells from a Patient Infected with Human T Cell Leukemia/lymphoma Virus

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1983 Sep 1
PMID 6604130
Citations 18
Authors
H Mitsuya
L A Matis
M Megson
P A Bunn
C Murray
D L Mann
R C Gallo
S Broder
Affiliations
Soon will be listed here.
Abstract

Lymphocytes from a patient who had an unusually long survival after therapy for a human T cell leukemia/lymphoma virus (HTLV)-associated T cell lymphoma were stimulated in vitro with an autologous tumor cell line, and the generation of cytotoxic T lymphocytes (CTL) was studied. CTL generated were directed against autologous (HTLV-associated tumor cells. These propagated CTL were OKT3+, OKT4-, and OKT8+. The cytotoxic activity required target tumor cells that were infected with HTLV and also expressed histocompatibility antigens in common with the patient, suggesting a major histocompatibility complex-restricted associative recognition of target antigens expressed on the tumor cell membrane.

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