Evidence for a New Lymphocyte-stimulating Determinant (Lsd) Detected by Alloreactive T Cell Lines

Overview

Journal Eur J Immunol

Specialty Allergy & Immunology

Date 1983 Jan 1

PMID 6601005

Citations 6

Authors

B Opalka

E Kolsch

Affiliations

Soon will be listed here.

Abstract

Three alloreactive T cell clones are described which reveal a new lymphocyte-stimulating determinant (Lsd) controlled by a gene on chromosome 1 of the mouse but different from and possibly centromeric to Mls. Two clones were originally isolated as anti-H-2b-specific and showed and retained cross-reactivity to Lsd (clone OD3, BALB/c anti-C57BL/6; clone KB37, B10.BR anti-C57BL/10). The third clone (BD7, C57BL/6 anti-CBA/J) was probably originally directed against Lsd. So far, Lsd is only characterized by stimulation of T cell proliferation, and its physiological function is not yet known.

Citing Articles

Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host resistance to mousepox.

Brownstein D, Gras L J Virol. 1995; 69(11):6958-64.

PMID: 7474114 PMC: 189614. DOI: 10.1128/JVI.69.11.6958-6964.1995.

Alloreactivity of an OVA-specific T-cell clone. I. Stimulation by class II MHC and novel non-MHC B-cell determinants.

Friedman S, Sillcocks D, CANTOR H Immunogenetics. 1987; 26(4-5):193-203.

PMID: 3498687 DOI: 10.1007/BF00346512.

Clonal analysis of the Mls system. A reappraisal of polymorphism and allelism among Mlsa, Mlsc, and Mlsd.

Abe R, Ryan J, Hodes R J Exp Med. 1987; 165(4):1113-29.

PMID: 2435833 PMC: 2188577. DOI: 10.1084/jem.165.4.1113.

Mouse map of paralogous genes.

Nadeau J, Kosowsky M Mamm Genome. 1991; 1 Spec No:S433-60.

PMID: 1799810 DOI: 10.1007/BF00656503.

Mouse chromosome 1.

Seldin M, Roderick T, Paigen B Mamm Genome. 1991; 1 Spec No:S1-17.

PMID: 1799793