Human Arterial Wall Cells Secrete Factors That Are Chemotactic for Monocytes

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1983 Aug 1

PMID 6576378

Citations 19

Authors

T Mazzone

M Jensen

A Chait

Affiliations

Soon will be listed here.

Abstract

Macrophages and arterial smooth muscle cells comprise the cellular components of the atherosclerotic plaque. The vessel wall accumulation of macrophages occurs by a process of increased circulating monocyte migration into the vessel wall. In these studies it is demonstrated that human macrophages and arterial smooth muscle cells in culture secrete potent chemotactic factors for freshly isolated human monocytes. In contrast, human fibroblast-conditioned medium has no chemotactic activity. The effect of macrophage-conditioned medium is a function of macrophage differentiation and can be potentiated by macrophage activation. These results suggest that secretory products of human macrophages and arterial smooth muscle cells may be important stimuli for increased monocyte migration into the vessel wall in vivo.

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