A Quantitative Electron Microscopic Study of the Ageing Human Cerebral Cortex

Overview

Journal Acta Neuropathol

Specialty Neurology

Date 1976 Dec 21

PMID 65101

Citations 11

Authors

S Rees

Affiliations

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Abstract

A recent quantitative electron microscopic study of biopsy samples of the cerebral cortex of neurologically normal individuals, aged between 15 and 54 years, has shown that atypical inclusions are present in neuronal and glial processes in small but appreciable numbers (Rees). It would be of interest to know whether these inclusions accumulate with age. This study therefore applied the same quantitative methods used in the previous study, to autopsy samples of frontal and temporal cortex from 3 non-demented ageing human brains (70-76 years). The results showed that in the areas of cortex examined, the number of inclusions in neuronal processes did not increase with age. However, the number of dense deposits in the cell bodies and processes of oligodendrocytes did increase significantly with age. In agreement with previous studies corpora amylacea were found in astrocytic processes. Senile plaques were not observed.

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References

Keefe J, Ordy J . INTRACELLULAR LOCALIZATION OF LIPOFUSCIN AGE PIGMENTS IN THE NERVOUS SYSTEM. J Gerontol. 1964; 19:262-76. DOI: 10.1093/geronj/19.3.262. View

COLONNIER M . EXPERIMENTAL DEGENERATION IN THE CEREBRAL CORTEX. J Anat. 1964; 98:47-53. PMC: 1261310. View

JOHNSON Jr J, Miquel J . Fine structural changes in the lateral vestibular nucleus of aging rats. Mech Ageing Dev. 1974; 3(3-4):203-24. DOI: 10.1016/0047-6374(74)90017-7. View

Anzil A, Herrlinger H, BLINZINGER K, Kronski D . Intraneuritic corpora amylacea. Demonstration in orbital cortex of elderly subjects by means of early postmortem brain sampling and electron microscopy. Virchows Arch A Pathol Anat Histol. 1974; 364(4):297-301. DOI: 10.1007/BF00432727. View

Hirano A, Sax D, Zimmerman H . The fine structure of the cerebella of jimpy mice and their "normal" litter mates. J Neuropathol Exp Neurol. 1969; 28(3):388-400. DOI: 10.1097/00005072-196907000-00003. View

Sotelo C, PALAY S . Altered axons and axon terminals in the lateral vestibular nucleus of the rat. Possible example of axonal remodeling. Lab Invest. 1971; 25(6):653-71. View

Lloret I, Saavedra J . Enlargement of synaptic vesicles in degenerating nerve endings: a comparison between cat and monkey. J Neurocytol. 1975; 4(1):1-6. DOI: 10.1007/BF01099090. View

McMahan U . Fine structure of synapses in the dorsal nucleus of the lateral geniculate body of normal and blinded rats. Z Zellforsch Mikrosk Anat. 1967; 76(1):116-46. DOI: 10.1007/BF00337036. View

BRIZZEE K, Cancilla P, Sherwood N, Timiras P . The amount and distribution of pigments in neurons and glia of the cerebral cortex. Autofluorescent and ultrastructural studies. J Gerontol. 1969; 24(2):127-35. DOI: 10.1093/geronj/24.2.127. View

10.

Cook R, Wisniewski H . The role of oligodendroglia and astroglia in Wallerian degeneration of the optic nerve. Brain Res. 1973; 61:191-206. DOI: 10.1016/0006-8993(73)90527-1. View

11.

Mann D, YATES P . Lipoprotein pigments--their relationship to ageing in the human nervous system. I. The lipofuscin content of nerve cells. Brain. 1974; 97(3):481-8. DOI: 10.1093/brain/97.1.481. View

12.

Rees S . A quantitative electron microscopic study of atypical structures in normal human cerebral cortex. Anat Embryol (Berl). 1975; 148(3):303-31. DOI: 10.1007/BF00319849. View

13.

Valdivia O . Methods of fixation and the morphology of synaptic vesicles. J Comp Neurol. 1971; 142(3):257-73. DOI: 10.1002/cne.901420302. View

14.

Wisniewski H, Terry R . Morphology of the aging brain, human and animal. Prog Brain Res. 1973; 40(0):167-86. DOI: 10.1016/S0079-6123(08)60686-X. View

15.

Dayan A . Comparative neuropathology of ageing. Studies on the brains of 47 species of vertebrates. Brain. 1971; 94(1):31-42. DOI: 10.1093/brain/94.1.31. View

16.

Sung J . NEUROAXONAL DYSTROPHY IN MUCOVISCIDOSIS. J Neuropathol Exp Neurol. 1964; 23:567-83. DOI: 10.1097/00005072-196410000-00001. View

17.

Tomlinson B, Blessed G, Roth M . Observations on the brains of non-demented old people. J Neurol Sci. 1968; 7(2):331-56. DOI: 10.1016/0022-510x(68)90154-8. View

18.

Dayan A . Quantitative histological studies on the aged human brain. I. Senile plaques and neurofibrillary tangles in "normal" patients. Acta Neuropathol. 1970; 16(2):85-94. DOI: 10.1007/BF00687663. View

19.

Gray E . Synaptic fine structure and nuclear, cytoplasmic and extracellular networks: The stereoframework concept. J Neurocytol. 1975; 4(3):315-39. DOI: 10.1007/BF01102116. View

20.

Ramsey H . ULTRASTRUCTURE OF CORPORA AMYLACEA. J Neuropathol Exp Neurol. 1965; 24:25-39. DOI: 10.1097/00005072-196501000-00003. View