The Gene for the Adenovirus 2 Hexon Polypeptide

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 1984 Nov 25

PMID 6501284

Citations 13

Authors

G Akusjarvi

P Alestrom

M Pettersson

M Lager

H Jornvall

U Pettersson

Affiliations

Soon will be listed here.

Abstract

The nucleotide sequence of the gene for the adenovirus type 2 hexon has been determined. The hexon polypeptide consists of 967 amino acid residues and has a molecular weight of 109,058. Several tentative parts in the previously reported amino acid sequence were resolved from the DNA sequence. The existence of regions with unusual properties in the hexon protein was confirmed, including a region consisting of 16 consecutive acidic residues in the N-terminal part of the protein. In conjunction with previously published sequences and sequences reported in the accompanying papers (Aleström, P., Akusjärvi, G., Lager, M., Yeh-Kai, L., and Petterson, U. (1984) J. Biol. Chem. 259, 13980-13985; Roberts, R. J., O'Neill, K. E., and Yen, C. E. (1984) J. Biol. Chem. 259, 13965-13975) a complete sequence of the 35,937-base pairs-long adenovirus type 2 genome can now be reconstructed.

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