Measles Virus and Inactivated Canine Distemper Virus Induce Incomplete Immunity to Canine Distemper

Overview

Journal Arch Virol

Specialty Microbiology

Date 1984 Jan 1

PMID 6497659

Citations 24

Authors

M J Appel

W R Shek

H Shesberadaran

E Norrby

Affiliations

Soon will be listed here.

Abstract

Pairs of specific pathogen free dogs were immunized with two injections of heat inactivated canine distemper virus (CDV) or one injection of a live CDV or live measles virus (MV) vaccine. Three unimmunized dogs were used as controls. All 9 dogs were challenged with virulent CDV (Snyder Hill strain). The three unimmunized dogs developed severe signs of disease with a lethal infection in one. The two dogs immunized with live CDV vaccine developed a strong humoral as well as cellular immune response after immunization and were protected against virus replication. Animals immunized with either inactivated CDV or modified live MV failed to develop a measurable cellular immune response after immunization and had a comparatively weak humoral immune response to distemper antigens. They showed mild signs of infection after challenge and responded with strong anamnestic cellular and humoral immunity. The measles vaccine immunized dogs had a moderate serum titer of measles hemolysin-inhibiting antibodies which, after exposure to distemper virus, was boosted to high levels. It is proposed that this response plays a role in the mitigation of the virulent distemper infection in these animals.

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References

Lerner R . Tapping the immunological repertoire to produce antibodies of predetermined specificity. Nature. 1982; 299(5884):593-6. DOI: 10.1038/299592a0. View

Brown A, McCarthy R . Relationship between measles and canine distemper viruses determined by delayed type hypersensitivity reactions in dogs. Nature. 1974; 248(446):344-5. DOI: 10.1038/248344a0. View

Armerding D, Rossiter H, Ghazzouli I, Liehl E . Evaluation of live and inactivated influenza A virus vaccines in a mouse model. J Infect Dis. 1982; 145(3):320-30. DOI: 10.1093/infdis/145.3.320. View

Appel M, Shek W, Summers B . Lymphocyte-mediated immune cytotoxicity in dogs infected with virulent canine distemper virus. Infect Immun. 1982; 37(2):592-600. PMC: 347574. DOI: 10.1128/iai.37.2.592-600.1982. View

Appel M, Robson D . A microneutralization test for canine distemper virus. Am J Vet Res. 1973; 34(11):1459-63. View

Krakowka S, Wallace A . Lymphocyte-associated immune responses to canine distemper and measles viruses in distemper-infected gnotobiotic dogs. Am J Vet Res. 1979; 40(5):669-72. View

Appel M . Pathogenesis of canine distemper. Am J Vet Res. 1969; 30(7):1167-82. View

Virelizier J, Allison A, Schild G . Immune responses to influenza virus in the mouse, and their role in control of the infection. Br Med Bull. 1979; 35(1):65-8. DOI: 10.1093/oxfordjournals.bmb.a071544. View

Krakowka S, Olsen R, Confer A, Koestner A, McCullough B . Serologic response to canine distemper viral antigens in gnotobiotic dogs infected with canine distemper virus. J Infect Dis. 1975; 132(4):384-92. DOI: 10.1093/infdis/132.4.384. View

10.

Norrby E, Gollmar Y . Identification of measles virus-specific hemolysis-inihibiting antibodies separate from hemagglutination-inhibiting antibodies. Infect Immun. 1975; 11(2):231-9. PMC: 415050. DOI: 10.1128/iai.11.2.231-239.1975. View

11.

Gillespie J . A STUDY OF INACTIVATED DISTEMPER VIRUS IN THE DOG. Cornell Vet. 1965; 55:1-8. View

12.

ANNUNZIATO D, Kaplan M, Hall W, Ichinose H, Lin J, Balsam D . Atypical measles syndrome: pathologic and serologic findings. Pediatrics. 1982; 70(2):203-9. View

13.

Braciale T, Yap K . Role of viral infectivity in the induction of influenza virus-specific cytotoxic T cells. J Exp Med. 1978; 147(4):1236-52. PMC: 2184234. DOI: 10.1084/jem.147.4.1236. View

14.

Mebus C, COLES E . Measles--canine distemper relationship. The effect of measles viruses and their influence on subsequent challenge with Snyder Hill distemper virus. Cornell Vet. 1966; 56(1):85-103. View

15.

Summers B, Greisen H, Appel M . Canine distemper encephalomyelitis: variation with virus strain. J Comp Pathol. 1984; 94(1):65-75. DOI: 10.1016/0021-9975(84)90009-4. View

16.

Shek W, Schultz R, Appel M . Natural and immune cytolysis of canine distemper virus-infected target cells. Infect Immun. 1980; 28(3):724-34. PMC: 551011. DOI: 10.1128/iai.28.3.724-734.1980. View

17.

Norrby E, Gollmar Y . Appearance and persistence of antibodies against different virus components after regular measles infections. Infect Immun. 1972; 6(3):240-7. PMC: 422522. DOI: 10.1128/iai.6.3.240-247.1972. View