Adenosine Deaminase Antagonizes Inhibitory Responses to Adenosine and Non-adrenergic, Non-cholinergic Inhibitory Nerve Stimulation in Isolated Preparations of Guinea-pig Trachea

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1984 Oct 1

PMID 6487899

Citations 3

Authors

D G Satchell

Affiliations

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Abstract

In guinea-pig isolated tracheal tube preparations treated with dipyridamole, adenosine deaminase antagonized inhibitory responses to adenosine and non-adrenergic, non-cholinergic nerve stimulation. Inhibitory responses to vasoactive intestinal peptide (VIP) were unaffected and hyoscine-sensitive excitatory responses to field stimulation were not reduced. The evidence supports a role of adenosine as an inhibitory neurotransmitter in non-adrenergic, non-cholinergic nerves in trachea.

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References

Coleman R . Effects of some purine derivatives on the guinea-pig trachea and their interaction with drugs that block adenosine uptake. Br J Pharmacol. 1976; 57(1):51-7. PMC: 1667005. DOI: 10.1111/j.1476-5381.1976.tb07655.x. View

Matsuzaki Y, Hamasaki Y, Said S . Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways. Science. 1980; 210(4475):1252-3. DOI: 10.1126/science.6254154. View

Christie J, Satchell D . Purine receptors in the trachea: is there a receptor for ATP?. Br J Pharmacol. 1980; 70(4):512-4. PMC: 2044384. DOI: 10.1111/j.1476-5381.1980.tb09768.x. View

Satchell D . Non-adrenergic, non-cholinergic nerves in mammalian airways: their function and the role of purines. Comp Biochem Physiol C Comp Pharmacol. 1982; 72(2):189-96. DOI: 10.1016/0306-4492(82)90083-1. View