Interaction of Pentobarbitone and Gamma-aminobutyric Acid on Mammalian Sympathetic Ganglion Cells

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1978 May 1

PMID 647160

Citations 16

Authors

D A Brown

A Constanti

Affiliations

Soon will be listed here.

Abstract

1. Interactions of bath-applied pentobarbitone and gamma-aminobutyric acid (GABA) on neurones in isolated superior cervical ganglia of the rat have been examined with intracellular microelectrodes. 2. Pentobarbitone itself (30 micrometer-1 mM) showed no clear or consistent GABA-like effects: changes in resting input conductance and membrane potential were small and variable. 3. Pentobarbitone (100 micrometer) strikingly enhanced the conductance increases produced by GABA and 3-aminopropanesulphonic acid, and reversed the depression of GABA-evoked responses by bicuculline. 4. It is concluded that reversal of bicuculline action at the membrane conductance level might be explained by augmentation of GABA-action. This augmentation cannot be attributed to 'partial agonist' properties of pentobarbitone or to interference with glial transport processes.

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Potentiation of inhibition by general anaesthetics in neurones of the olfactory cortex in vitro.

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