Musculoskeletal Manifestations of Paget's Disease of Bone

Overview

Journal Arthritis Rheum

Specialty Rheumatology

Date 1980 Oct 1

PMID 6448603

Citations 23

Authors

R D Altman

Affiliations

Soon will be listed here.

Abstract

A review of 290 patients with Paget's disease of bone revealed 83% had one or more rheumatic syndromes. The most common finding was back pain (37%), most often related to an independent osteoarthritic process or Paget's disease precipitating or complicating spinal osteoarthritis. Paget's disease as a sole source of back pain was distinctly uncommon (2%). Osteoarthritis related to Paget's disease was present in the hip (30%) and knee (11%). Paget's disease in spondylitis was present in 4 patients and in ankylosing hyperostosis in 4 patients. The latter group had very active Paget's disease. Rheumatoid arthritis (1%), hyperuricemia (20%), and gout (4%) did not appear increased in this group.

Citing Articles

Causes of Musculoskeletal Pain in Paget's Disease of Bone.

Berg K, Dockrell D, Colvin L, Fraser W, Tang J, Aspray T Calcif Tissue Int. 2024; 115(5):533-541.

PMID: 39349622 PMC: 11531417. DOI: 10.1007/s00223-024-01279-0.

A mutation in the ZNF687 gene that is responsible for the severe form of Paget's disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model.

Russo S, Scotto di Carlo F, Maurizi A, Fortunato G, Teti A, Licastro D Bone Res. 2023; 11(1):16.

PMID: 36918542 PMC: 10014847. DOI: 10.1038/s41413-023-00250-3.

Spinal Paget's disease with bilevel cord compression and ischemic non-compressive myelopathy treated with zoledronic acid.

Feki A, Sellami I, Gassara Z, Ben Djemaa S, Ezzeddine M, Kallel M Clin Case Rep. 2022; 10(8):e6263.

PMID: 35999985 PMC: 9388838. DOI: 10.1002/ccr3.6263.

Headache in patients with Paget's Disease of Bones.

Evangelatos G, Iliopoulos A J Frailty Sarcopenia Falls. 2020; 2(2):16-20.

PMID: 32300678 PMC: 7155377.

A Case of Rheumatoid Arthritis and Paget Disease of Bone.

Borz-Baba C, Sachan Y, Sapers B, Georgescu L Am J Case Rep. 2019; 20:764-769.

PMID: 31142731 PMC: 6558118. DOI: 10.12659/AJCR.914668.