Directionality and Nonreciprocality of Chi-stimulated Recombination in Phage Lambda

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 1980 Feb 1

PMID 6446478

Citations 33

Authors

F W Stahl

M M Stahl

R E Malone

J M Crasemann

Affiliations

Soon will be listed here.

Abstract

Chi's are genetic elements that stimulate generalized recombination in their locale in phage lambda. All Chi's wherever located on lambda's chromosome, act asymmetrically in crosses blocked in DNA replication: (1) They stimulate exchange primarily to their left on the conventional lambda map, and (2) the stimulated exchange is frequently nonreciprocal, the recombinant carrying the Chi element being produced less often than the complementary product.

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RecBCD enzyme and Chi recombination hotspots as determinants of self vs. non-self: Myths and mechanisms.

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The lambda red proteins promote efficient recombination between diverged sequences: implications for bacteriophage genome mosaicism.

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References

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