Intragastric Bacterial Activity and Nitrosation Before, During, and After Treatment with Omeprazole

Overview

Journal Br Med J (Clin Res Ed)

Specialty General Medicine

Date 1984 Sep 22

PMID 6434053

Citations 56

Authors

B K Sharma

I A Santana

E C Wood

R P Walt

M Pereira

P Noone

P L Smith

C L Walters

R E Pounder

Affiliations

Soon will be listed here.

Abstract

Ten healthy volunteers were studied before, during, and after treatment with omeprazole 30 mg daily for two weeks. On the 14th night mean nocturnal (2100-0700) intragastric acidity was significantly decreased by 75% (p less than 0.001). At 0700, 22 hours after the last dose of omeprazole, there were significant increases in the bacterial count and the nitrite and N-nitrosamine concentrations in the gastric juice (p less than 0.001). Three days later these changes had resolved. Short term treatment of healthy volunteers with omeprazole is associated with a short lived increase in the gastric bacterial flora, with endogenous production of N-nitroso compounds.

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