Optimal Dose of Oral Omeprazole for Maximal 24 Hour Decrease of Intragastric Acidity

Overview

Journal Gut

Specialty Gastroenterology

Date 1984 Sep 1

PMID 6469081

Citations 66

Authors

B K Sharma

R P Walt

R E Pounder

M D Gomes

E C Wood

L H LOGAN

Affiliations

Soon will be listed here.

Abstract

In a series of 59 experiments in nine duodenal ulcer patients, 24 hour intragastric acidity was measured before, during, and after treatment with daily oral omeprazole. Omeprazole 10, 20, and 30 mg/day for one week caused a 37, 90, and 97% decrease of 24 hour intragastric acidity, respectively. No further decrease of acidity was observed when the dose of omeprazole was doubled to 60 mg/day, or after a second week of treatment with 30 mg/day. One week after stopping treatment with omeprazole (14 doses) there was a significant 26% decrease of 24 hour intragastric acidity, with full recovery seven weeks later. Fasting plasma gastrin concentration was significantly raised during treatment with all doses of omeprazole. Omeprazole 30 mg/day is the optimal dose for a maximal decrease of 24 hour intragastric acidity in duodenal ulcer patients.

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