Specific Oculomotor Deficits After Amylobarbitone

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1983 Jan 1

PMID 6405427

Citations 6

Authors

G Tedeschi

P R Bittencourt

A T Smith

A Richens

Affiliations

Soon will be listed here.

Abstract

Five healthy volunteers received a single oral dose of amylobarbitone sodium (200 mg) and placebo in a double blind randomized fashion. Peak velocity of horizontal saccadic eye movements, saccade duration and smooth pursuit velocity were measured at intervals up to 6 h after drug administration. The active treatment produced a statistically significant decrease of both saccadic and smooth pursuit eye velocity. The maximum effect was observed 2 h after drug administration. The effect on peak saccadic velocity was still statistically significant 6 h after treatment. The maximum impairment in eye movement performance ranged between 25 and 29%. These results demonstrate that both saccadic and smooth pursuit systems are unable to generate the required eye velocity under the influence of a therapeutic dose of amylobarbitone sodium.

Citing Articles

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References

WILKINSON I, Kime R, Purnell M . Alcohol and human eye movement. Brain. 1974; 97(4):785-92. DOI: 10.1093/brain/97.1.785. View

Bittencourt P, Gresty M, Richens A . Quantitative assessment of smooth-pursuit eye movements in healthy and epileptic subjects. J Neurol Neurosurg Psychiatry. 1980; 43(12):1119-24. PMC: 490785. DOI: 10.1136/jnnp.43.12.1119. View

RASHBASS C, Russell G . Action of a barbiturate drug (amylobarbitone sodium) on the vestibulo-ocular reflex. Brain. 1961; 84:329-35. DOI: 10.1093/brain/84.2.329. View

Okuma T, SHIMAZONO Y, Fukuda T, Narabayashi H . Cortical and subcortical recordings in non-anesthetized and anesthetized periods in man. Electroencephalogr Clin Neurophysiol. 1954; 6(2):269-86. DOI: 10.1016/0013-4694(54)90029-2. View

Rothenberg S, Selkoe D . Specific oculomotor deficit after diazepam. I. Saccadic eye movements. Psychopharmacology (Berl). 1981; 74(3):232-6. DOI: 10.1007/BF00427100. View

Schneider J, Thomalske G . [Pharmacodynamic exploration of the cortex and subcortical structures and its electrographic criteria; determination of sites of lesion in men by means of pentothal technic]. Electroencephalogr Clin Neurophysiol. 1956; 8(3):353-69. DOI: 10.1016/0013-4694(56)90001-3. View

Rothenberg S, Schottenfeld S, Selkoe D, Gross K . Specific oculomotor deficit after acute methadone. II. Smooth pursuit eye movements. Psychopharmacology (Berl). 1980; 67(3):229-34. DOI: 10.1007/BF00431261. View

Barlow J, Rovit R, Gloor P . CORRELATION ANALYSIS OF EEG CHANGES INDUCED BY UNILATERAL INTRACAROTID INJECTION OF AMOBARBITAL. Electroencephalogr Clin Neurophysiol. 1964; 16:213-20. DOI: 10.1016/0013-4694(64)90104-x. View

Malpas A . Subjective and objective effects of nitrazepam and amylobarbitone sodium in normal human beings. Psychopharmacologia. 1972; 27(4):373-8. DOI: 10.1007/BF00429391. View

10.

Hindmarch I, Parrott A, Arenillas L . A repeated dose comparison of dichloralphenazone, flunitrazepam and amylobarbitone sodium on some aspects of sleep and early morning behaviour in normal subjects. Br J Clin Pharmacol. 1977; 4(2):229-33. PMC: 1429004. DOI: 10.1111/j.1365-2125.1977.tb00699.x. View

11.

Hart J, HILL H, Bye C, WILKINSON R, Peck A . The effects of low doses of amylobarbitone sodium and diazepam on human performance. Br J Clin Pharmacol. 1976; 3(2):289-98. PMC: 1428881. DOI: 10.1111/j.1365-2125.1976.tb00606.x. View

12.

Bittencourt P, Wade P, Smith A, Richens A . Benzodiazepines impair smooth pursuit eye movements. Br J Clin Pharmacol. 1983; 15(2):259-62. PMC: 1427870. DOI: 10.1111/j.1365-2125.1983.tb01495.x. View

13.

Brazier M . Prenarcotic doses of barbiturates as an aid in localizing diseased brain tissue. Anesthesiology. 1969; 31(1):78-83. DOI: 10.1097/00000542-196907000-00023. View

14.

Okuma T, SHIMAZONO Y, Narabayashi H . Cortical and subcortical electrograms in anesthesia and anoxia in man. Electroencephalogr Clin Neurophysiol. 1957; 9(4):609-22. DOI: 10.1016/0013-4694(57)90083-4. View

15.

Keller E . Participation of medial pontine reticular formation in eye movement generation in monkey. J Neurophysiol. 1974; 37(2):316-32. DOI: 10.1152/jn.1974.37.2.316. View

16.

Baloh R, Sharma S, Moskowitz H, Griffith R . Effect of alcohol and marijuana on eye movements. Aviat Space Environ Med. 1979; 50(1):18-23. View

17.

Bittencourt P, Wade P, Smith A, Richens A . The relationship between peak velocity of saccadic eye movements and serum benzodiazepine concentration. Br J Clin Pharmacol. 1981; 12(4):523-33. PMC: 1401908. DOI: 10.1111/j.1365-2125.1981.tb01261.x. View

18.

Rothenberg S, Schottenfeld S, Gross K, Selkoe D . Specific oculomotor deficit after acute methadone. I. Saccadic eye movements. Psychopharmacology (Berl). 1980; 67(3):221-7. DOI: 10.1007/BF00431260. View

19.

Smith A, Bittencourt P, Lloyd D, Richens A . An efficient technique for determining characteristics of saccadic eye movements using a mini computer. J Biomed Eng. 1981; 3(1):39-43. DOI: 10.1016/0141-5425(81)90103-5. View

20.

Rothenberg S, Selkoe D . Specific oculomotor deficit after diazepam. II. Smooth pursuit eye movements. Psychopharmacology (Berl). 1981; 74(3):237-40. DOI: 10.1007/BF00427101. View