Synthetic Fc Peptide-mediated Regulation of the Immune Response. I. Characterization of the Immunomodulating Properties of a Synthetic 23-amino Acid Peptide Derived from the Sequence of the CH3 Domain of Human IgG1

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1983 Mar 1

PMID 6403651

Citations 2

Authors

E L MORGAN

J E Shields

C S Campbell

R L BARTON

G A Koppel

W O Weigle

Affiliations

Soon will be listed here.

Abstract

A synthetic 23-amino acid peptide derived from the CH3 domain of human IgG1 was found to be a potent adjuvant as well as a polyclonal activator. The Fc peptide was found to enhance human and murine humoral, and T cell-mediated immune responses. Moreover, in vivo administration of Fc peptide enhanced murine natural killer cell activity. The synthetic Fc peptide was found to be more potent, on a molar basis, than native Fc fragments in inducing polyclonal antibody production and potentiating immune responses.

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