The Activity of Natural Cytotoxic Cells is Augmented by Interleukin 2 and Interleukin 3

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1983 Mar 1

PMID 6403648

Citations 18

Authors

E C Lattime

G A Pecoraro

O Stutman

Affiliations

Soon will be listed here.

Abstract

Murine natural killer (NK) and natural cytotoxic (NC) cells showed different patterns of augmentation of lytic activity after preincubation for 24 h with either poly-IC, interleukin 2 (IL-2), or interleukin 3 (IL-3): (a) Poly-IC augmented only NK cells, with no effect on NC activity, as we have previously observed (4); (b) IL-2 augmented both NK and NC activity; and (c) IL-3 augmented only NC lysis, without affecting NK activity. In addition, both precursor and the augmented effector cells showed differences in expression of the Qa-5 surface marker: NK precursors and effectors are Qa 5+, whereas NC precursors and effector cells are Qa-5-.

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Augmentation of organ-associated natural killer activity by biological response modifiers. Isolation and characterization of large granular lymphocytes from the liver.

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In vitro generated mast cells express natural cytotoxicity against tumour cells.

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