Bone Structure, Composition, and Mineralization

Overview

Journal Orthop Clin North Am

Specialty Orthopedics

Date 1984 Oct 1

PMID 6387574

Citations 26

Authors

A L Boskey

A S Posner

Affiliations

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Abstract

Bone structure and function are dependent on complex interactions between cells, matrix, cell-derived factors, and systemic factors. The deposition of mineral in bone, which enables the skeleton to function properly, is described as a four-step process of matrix modification, crystal nucleation, crystal growth, and remodeling. Insight into the function of bone components in the mineralization process is provided by in vitro studies and analysis of abnormal calcifications.

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