The Effect of Insulin on Fru-2,6-P2 Levels in Human Fibroblasts

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1984 Jun 4

PMID 6373374

Citations 8

Authors

M Farnararo

V Vasta

P Bruni

A DAlessandro

Affiliations

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Abstract

We report that fructose 2,6-bisphosphate (Fru-2,6-P2) levels in quiescent human fibroblasts stimulated with insulin treatment increase in a time- and dose-dependent manner. The biochemical role of the sugar phosphate in the cellular response to the hormone which controls carbohydrate metabolism and acts as mitogenic factor is discussed.

Citing Articles

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: head-to-head with a bifunctional enzyme that controls glycolysis.

Rider M, Bertrand L, Vertommen D, Michels P, Rousseau G, Hue L Biochem J. 2004; 381(Pt 3):561-79.

PMID: 15170386 PMC: 1133864. DOI: 10.1042/BJ20040752.

Fructose 2,6-bisphosphate metabolism during megakaryocytic differentiation of K562 and MEG-01 cells.

Meacci E, Vasta V, Farnararo M, Bruni P Mol Cell Biochem. 1996; 156(2):125-30.

PMID: 9095468 DOI: 10.1007/BF00426334.

Effect of glutamine on fructose 2,6-bisphosphate and on glucose metabolism in HeLa cells and in chick-embryo fibroblasts.

Mojena M, Bosca L, Hue L Biochem J. 1985; 232(2):521-7.

PMID: 2936331 PMC: 1152911. DOI: 10.1042/bj2320521.

Phorbol 12-myristate 13-acetate and insulin increase the concentration of fructose 2,6-bisphosphate and stimulate glycolysis in chicken embryo fibroblasts.

Bosca L, Rousseau G, Hue L Proc Natl Acad Sci U S A. 1985; 82(19):6440-4.

PMID: 2931720 PMC: 390732. DOI: 10.1073/pnas.82.19.6440.

Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues.

Hue L, Rider M Biochem J. 1987; 245(2):313-24.

PMID: 2822019 PMC: 1148124. DOI: 10.1042/bj2450313.