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Synergism of Imipenem and Amikacin in Combination with Other Antibiotics Against Nocardia Asteroides

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1983 Nov 1
PMID 6362558
Citations 19
Authors
M E Gombert
T M Aulicino
Affiliations
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Abstract

The in vitro activities of imipenem (formerly imipemide, N-formimidoyl thienamycin, or MK0787) and amikacin in combination with cefotaxime, trimethoprim-sulfamethoxazole, and each other were tested against 26 Nocardia asteroides strains. The agar dilution method was used for all tests. Synergy was present in 80% of tests with imipenem-trimethoprim-sulfamethoxazole, in 92% of tests with imipenem-cefotaxime, and in 83% of tests with amikacin-trimethoprim-sulfamethoxazole. Indifference was found on rare occasions, and no antagonism was seen.

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References
1.
Orfanakis M, WILCOX H, Smith C . In vitro studies of the combined effect of ampicillin and sulfonamides on Nocardia asteroides and results of therapy in four patients. Antimicrob Agents Chemother. 1972; 1(3):215-20. PMC: 444195. DOI: 10.1128/AAC.1.3.215. View
2.
Bach M, GOLD O, FINLAND M . Activity of minocycline against Nocardia asteroides: comparison with tetracycline in agar-dilution and standard disc-diffusion tests and with sulfadiazine in an experimental infection of mice. J Lab Clin Med. 1973; 81(5):787-93. View
3.
Bach M, Monaco A, FINLAND M . Pulmonary nocardiosis. Therapy with minocycline and with erythromycin plus ampicillin. JAMA. 1973; 224(10):1378-81. DOI: 10.1001/jama.224.10.1378. View
4.
Gombert M . Susceptibility of Nocardia asteroides to various antibiotics, including newer beta-lactams, trimethoprim-sulfamethoxazole, amikacin, and N-formimidoyl thienamycin. Antimicrob Agents Chemother. 1982; 21(6):1011-2. PMC: 182064. DOI: 10.1128/AAC.21.6.1011. View
5.
Smego Jr R, Moeller M, Gallis H . Trimethoprim-sulfamethoxazole therapy for Nocardia infections. Arch Intern Med. 1983; 143(4):711-8. View