Reproductive Toxicity of the Glycol Ethers

Overview

Journal Toxicology

Publisher Elsevier

Specialty Toxicology

Date 1983 Jun 1

PMID 6351353

Citations 18

Authors

B D Hardin

Affiliations

Soon will be listed here.

Abstract

The glycol ethers are an important and widely used class of solvents. Recent studies have demonstrated that ethylene glycol monomethyl ether (EGME), ethylene glycol dimethyl ether (EGdiME), ethylene glycol monoethyl ether (EGEE), and ethylene glycol monoethyl ether acetate (EGEEA) are teratogenic. Other studies have demonstrated that testicular atrophy or infertility follow treatment of males with EGME, ethylene glycol monomethyl ether acetate (EGMEA), EGEE, EGEEA, diethylene glycol dimethyl ether (diEGdiME), and diethylene glycol monoethyl ether (diEGEE). Experimental data are reviewed and structure-activity relationships are speculated upon.

Citing Articles

Methyl and Ethyl Ethers of Glycerol as Potential Green Low-Melting Technical Fluids.

Samoilov V, Lavrentev V, Sultanova M, Ramazanov D, Kozhevnikov A, Shandryuk G Molecules. 2023; 28(22).

PMID: 38005206 PMC: 10672826. DOI: 10.3390/molecules28227483.

Refine and Strengthen SAR-Based Read-Across by Considering Bioactivation and Modes of Action.

Yan G, Rose J, Ellison C, Mudd A, Zhang X, Wu S Chem Res Toxicol. 2023; 36(9):1532-1548.

PMID: 37594911 PMC: 10523590. DOI: 10.1021/acs.chemrestox.3c00156.

Methyl cellosolve-induced renal oxidative stress and time-dependent up-regulation of pro-inflammatory cytokines, apoptotic, and oncogenic markers in rats.

Somade O, Ajayi B, Olushola M, Omoseebi E Toxicol Rep. 2020; 7:779-787.

PMID: 32642444 PMC: 7332505. DOI: 10.1016/j.toxrep.2020.06.007.

Small RNAs in Rat Sperm Are a Predictive and Sensitive Biomarker of Exposure to the Testicular Toxicant Ethylene Glycol Monomethyl Ether.

Stermer A, Reyes G, Hall S, Boekelheide K Toxicol Sci. 2019; 169(2):399-408.

PMID: 30768127 PMC: 6934889. DOI: 10.1093/toxsci/kfz041.

Toxicity of ethylene glycol monomethyl ether: impact on testicular gene expression.

Bagchi G, Waxman D Int J Androl. 2008; 31(2):269-74.

PMID: 18179559 PMC: 3286123. DOI: 10.1111/j.1365-2605.2007.00846.x.