Graves' Disease: in Situ Localization of Lymphoid T Cell Subpopulations

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1983 May 1

PMID 6345038

Citations 11

Authors

M C Bene

V Derennes

G Faure

J L Thomas

J Duheille

J Leclere

Affiliations

Soon will be listed here.

Abstract

An in situ analysis of immunological features in thyroids from 15 Graves' disease patients has been performed. This study included a search for immune complexes visualized near the follicle's basement membranes with fluorescent rabbit antisera to human IgG, IgA, IgM, C1q, C3 and C9. Cellular immunity was investigated on the humoral side by visualization of B cells and plasma cells. Two series of monoclonal antibodies (OKT3, 4 and 8, Leu 1, 2a and 3a) were used to label the infiltrating cells' membrane. These studies demonstrated the prevalence of T cells, a majority of them with OKT8/Leu 2a suppressor/cytotoxic phenotype. No correlation was found between this observation and peripheral blood T cell subsets analysis.

Citing Articles

Association between the TAP2 gene codon 665 polymorphism and Graves' disease.

Chen R, Wang T, Chen W, Tsai C, Tsai F J Clin Lab Anal. 2006; 20(3):93-7.

PMID: 16721835 PMC: 6807603. DOI: 10.1002/jcla.20107.

Association between the TAP1 gene codon 637 polymorphism and Graves' disease.

Chen R, Chen W, Chen C, Tsai C, Tsai F Endocrine. 2005; 25(2):137-40.

PMID: 15711027 DOI: 10.1385/ENDO:25:2:137.

Perforin expression by thyroid-infiltrating T cells in autoimmune thyroid disease.

Wu Z, Podack E, McKenzie J, Olsen K, Zakarija M Clin Exp Immunol. 1994; 98(3):470-7.

PMID: 7994911 PMC: 1534489. DOI: 10.1111/j.1365-2249.1994.tb05515.x.

Transplantation of human hyperthyroid tissue to the nude mouse. An experimental model.

Vignaud J, DUPREZ A, Bene M, Leclere J, Faure G, Danchin N Am J Pathol. 1984; 117(3):355-9.

PMID: 6548875 PMC: 1900575.

Autoimmune thyroid disease: purification and phenotypic analysis of intrathyroid T cells.

Canonica G, Caria M, Torre G, Risso A, Cosulich M, Bagnasco M J Endocrinol Invest. 1984; 7(6):641-5.

PMID: 6335716 DOI: 10.1007/BF03349499.

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