Autoimmune Thyroid Disease: Purification and Phenotypic Analysis of Intrathyroid T Cells

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 1984 Dec 1

PMID 6335716

Citations 6

Authors

G W Canonica

M Caria

G Torre

A Risso

M E Cosulich

M Bagnasco

Affiliations

Soon will be listed here.

Abstract

A phenotypic analysis of T cells infiltrating the thyroid of patients with autoimmune thyroid disease (both Graves' disease and Hashimoto's thyroiditis) was performed. T lymphocytes were purified from mononuclear cells extracted from surgically removed tissue. The following markers were evaluated: la antigens, MLR4 antigen (expressed on activated T cells) 5/9 antigen (expressed on a subset of lymphocytes containing the whole "helper-inducer" activity in vitro), Fc gamma-receptors, B9 antigen (expressed by cytotoxic, or precursor of cytotoxic, T cells). We observed increased percentages of 5/9-, MLR4- and la-positive T cells with respect to peripheral blood in both HT and GD: on the contrary, in specimens from nonautoimmune thyroid diseases mononuclear infiltrate was minimal, and even T cell evaluation was not possible. In addition, B9- and Fc gamma-positive T cells were increased in Hashimoto's, but not in Graves' thyroid tissue, thus suggesting a different role of cytotoxic effector mechanisms in the two diseases.

Citing Articles

Increased generation of fibrocytes in thyroid-associated ophthalmopathy.

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Intrathyroidal lymphocyte subsets, including unusual CD4+ CD8+ cells and CD3loTCR alpha beta lo/-CD4-CD8- cells, in autoimmune thyroid disease.

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T cell-mediated mechanisms in autoimmune thyroiditis.

Canonica G, Bagnasco M, Kong Y Immunol Res. 1986; 5(4):305-13.

PMID: 2955059 DOI: 10.1007/BF02935503.

Expression of intercellular adhesion molecule-1 (ICAM-1) on thyroid epithelial cells in Hashimoto's thyroiditis but not in Graves' disease or papillary thyroid cancer.

Bagnasco M, Caretto A, Olive D, Pedini B, Canonica G, Betterle C Clin Exp Immunol. 1991; 83(2):309-13.

PMID: 1671565 PMC: 1535249. DOI: 10.1111/j.1365-2249.1991.tb05633.x.

Expression of very late activation antigen-1 on intrathyroid lymphocytes in autoimmune thyroid disease.

Paolieri F, Pesce G, Torre G, Canonica G, Bagnasco M J Endocrinol Invest. 1992; 15(1):63-6.

PMID: 1560193 DOI: 10.1007/BF03348664.

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