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Selection and Characterization of Beta-lactam-resistant Escherichia Coli K-12 Mutants

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1983 Apr 1
PMID 6344786
Citations 28
Authors
A Jaffe
Y A CHABBERT
E DERLOT
Affiliations
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Abstract

beta-Lactam-resistant mutants of Escherichia coli K-12 were selected by using 12 different beta-lactam derivatives. The mutants fell into three categories showing (i) altered permeation through reduction or loss of outer membrane porin proteins (including ompF, ompR, and envZ alleles); (ii) increase in the rate of synthesis of chromosomally mediated beta-lactamase; or (iii) defective synthesis or action of cyclic adenosine 3',5'-phosphate (cya and crp alleles).

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