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Vibrio Cholerae Hemagglutinin/lectin/protease Hydrolyzes Fibronectin and Ovomucin: F.M. Burnet Revisited

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Specialty Science
Date 1983 Feb 1
PMID 6341990
Citations 72
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Abstract

Cholera vibrios produce a single polymeric protein that (i) causes hemagglutination; (ii) appears to participate in their attachment to gut epithelium; (iii) may mediate their detachment from gut epithelium; and (iv) is a protease that hydrolyzes fibronectin and mucin, cleaves lactoferrin, and nicks the A subunit of the choleragen-related heat-labile enterotoxin of Escherichia coli.

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References
1.
Finkelstein R, Sobocinski P, Atthasampunna P, Charunmethee P . Pathogenesis of experimental cholera: identification of choleragen (procholeragen A) by disc immunoelectrophoresis and its differentiation from cholera mucinase. J Immunol. 1966; 97(1):25-33. View

2.
Agin P, Gartner T . A novel method for purification of plasma fibronectin. Biochim Biophys Acta. 1982; 716(3):443-5. DOI: 10.1016/0304-4165(82)90039-3. View

3.
Marchalonis J . An enzymic method for the trace iodination of immunoglobulins and other proteins. Biochem J. 1969; 113(2):299-305. PMC: 1184636. DOI: 10.1042/bj1130299. View

4.
Laemmli U . Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227(5259):680-5. DOI: 10.1038/227680a0. View

5.
Finkelstein R, Fujita K, LoSpalluto J . Procholeragenoid: an aggregated intermediate in the formation of choleragenoid. J Immunol. 1971; 107(4):1043-51. View