Nonspecific Recruitment of Cytotoxic Effector Cells in the Intestinal Mucosa of Antigen-primed Mice

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1984 Dec 1

PMID 6334717

Citations 18

Authors

J R Klein

M F Kagnoff

Affiliations

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Abstract

We have examined cytotoxic responses of lymphocytes derived from the gut epithelium of mice primed systemically and enterically with alloantigens. Both gut intraepithelial (IEL) and splenic lymphocytes from alloantigen-primed mice were found to contain antigen-specific cytotoxic T cell activity. However, after priming, gut IEL also developed high levels of natural killer and spontaneous cytotoxic cell activities. We suggest that this nonspecific activation of additional cytotoxic effector populations during an antigen-specific response is an important host immune defense within the intestinal mucosa.

Citing Articles

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Ishizuka S, Ito S, Onuma M, Kasai T, Aoyama Y, Hara H Carcinogenesis. 1999; 20(6):1005-9.

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An unique CD4+CD8+ intestinal intraepithelial lymphocyte specific for DnaK (Escherichia coli HSP70) may be selected by intestinal microflora of rats.

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Modulation of intestinal and systemic immune responses to a fed protein antigen, in mice.

Strobel S, Ferguson A Gut. 1986; 27(7):829-37.

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