Neurotransmitter Receptors Mediate Cyclic GMP Formation by Involvement of Arachidonic Acid and Lipoxygenase

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1984 Jun 1

PMID 6328532

Citations 22

Authors

R M Snider

M McKinney

C Forray

E Richelson

Affiliations

Soon will be listed here.

Abstract

Evidence is presented that has led us to abandon the hypothesis that receptor-mediated cyclic GMP formation in cultured nerve cells occurs via the influx of extracellular calcium ions and an increase in the cytosolic free calcium ion concentration. While the cyclic GMP response is absolutely dependent on the presence of Ca2+, there is no increase in free intracellular Ca2+ subsequent to agonist stimulation. Instead, we have found that muscarinic or histamine H1 receptor stimulation elicits the release of arachidonic acid through a quinacrine-sensitive mechanism, possibly phospholipase A2. Inhibition of the release or metabolism of arachidonate by the lipoxygenase pathway prevents receptor-mediated cyclic GMP formation. We hypothesize that neurotransmitter receptors that mediate cyclic GMP synthesis function by releasing arachidonic acid and that an oxidative metabolite of arachidonic acid then stimulates soluble guanylate cyclase.

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References

Shier W . Activation of high levels of endogenous phospholipase A2 in cultured cells. Proc Natl Acad Sci U S A. 1979; 76(1):195-9. PMC: 382904. DOI: 10.1073/pnas.76.1.195. View

Study R, Breakefield X, Bartfai T, Greengard P . Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclic monophosphate levels in neuroblastoma cells. Proc Natl Acad Sci U S A. 1978; 75(12):6295-9. PMC: 393168. DOI: 10.1073/pnas.75.12.6295. View

Spies C, Schultz K, Schultz G . Inhibitory effects of mepacrine and eicosatetraynoic acid on cyclic GMP elevations caused by calcium and hormonal factors in rat ductus deferens. Naunyn Schmiedebergs Arch Pharmacol. 1980; 311(1):71-7. DOI: 10.1007/BF00500305. View

Craven P, Derubertis F . Calcium and O2-dependent control of inner medullary cGMP: possible role for Ca2+-dependent arachiodonate release and prostaglandin synthesis in expression of the action of osmolality on renal inner medullary guanosine 3'5' monophosphate. Metabolism. 1980; 29(9):842-53. DOI: 10.1016/0026-0495(80)90123-7. View

Richelson E . Regulation of muscarinic receptor-mediated cyclic GMP synthesis by cultured mouse neuroblastoma cells. J Neurochem. 1980; 35(4):941-8. DOI: 10.1111/j.1471-4159.1980.tb07093.x. View

Richelson E . Involvement of calcium channels in short-term desensitization of muscarinic receptor-mediated cyclic GMP formation in mouse neuroblastoma cells. Proc Natl Acad Sci U S A. 1980; 77(11):6897-901. PMC: 350398. DOI: 10.1073/pnas.77.11.6897. View

Lapetina E, Billah M, Cuatrecasas P . The initial action of thrombin on platelets. Conversion of phosphatidylinositol to phosphatidic acid preceding the production of arachidonic acid. J Biol Chem. 1981; 256(10):5037-40. View

Lapetina E, Billah M, Cuatrecasas P . The phosphatidylinositol cycle and the regulation of arachidonic acid production. Nature. 1981; 292(5821):367-9. PMC: 7094967. DOI: 10.1038/292367a0. View

Ohsako S, Deguchi T . Stimulation of phosphatidic acid of calcium influx and cyclic GMP synthesis in neuroblastoma cells. J Biol Chem. 1981; 256(21):10945-8. View

10.

Berridge M . Phosphatidylinositol hydrolysis: a multifunctional transducing mechanism. Mol Cell Endocrinol. 1981; 24(2):115-40. DOI: 10.1016/0303-7207(81)90055-1. View

11.

Schultz G, Hardman J, Schultz K, Baird C, SUTHERLAND E . The importance of calcium ions for the regulation of guanosine 3':5'-cyclic monophosphage levels. Proc Natl Acad Sci U S A. 1973; 70(12):3889-93. PMC: 427351. DOI: 10.1073/pnas.70.12.3889. View

12.

Michell R . Inositol phospholipids and cell surface receptor function. Biochim Biophys Acta. 1975; 415(1):81-47. DOI: 10.1016/0304-4157(75)90017-9. View

13.

Matsuzawa H, Nirenberg M . Receptor-mediated shifts in cGMP and cAMP levels in neuroblastoma cells. Proc Natl Acad Sci U S A. 1975; 72(9):3472-6. PMC: 433016. DOI: 10.1073/pnas.72.9.3472. View

14.

Richelson E . The molecular basis of neurotransmission at the muscarinic receptor. Biochem Pharmacol. 1981; 30(21):2887-91. DOI: 10.1016/0006-2952(81)90248-3. View

15.

Billah M, Lapetina E . Formation of lysophosphatidylinositol in platelets stimulated with thrombin or ionophore A23187. J Biol Chem. 1982; 257(9):5196-200. View

16.

Leiber D, Harbon S . The relationship between the carbachol stimulatory effect on cyclic GMP content and activation by fatty acid hydroperoxides of a soluble guanylate cyclase in the guinea pig myometrium. Mol Pharmacol. 1982; 21(3):654-63. View

17.

Morgan J, Morgan K . Vascular smooth muscle: the first recorded Ca2+ transients. Pflugers Arch. 1982; 395(1):75-7. DOI: 10.1007/BF00584972. View

18.

BLINKS J, Wier W, Hess P, Prendergast F . Measurement of Ca2+ concentrations in living cells. Prog Biophys Mol Biol. 1982; 40(1-2):1-114. DOI: 10.1016/0079-6107(82)90011-6. View

19.

Prescott S, MAJERUS P . Characterization of 1,2-diacylglycerol hydrolysis in human platelets. Demonstration of an arachidonoyl-monoacylglycerol intermediate. J Biol Chem. 1983; 258(2):764-9. View

20.

Agranoff B, Murthy P, Seguin E . Thrombin-induced phosphodiesteratic cleavage of phosphatidylinositol bisphosphate in human platelets. J Biol Chem. 1983; 258(4):2076-8. View