Amphipathic Analysis and Possible Formation of the Ion Channel in an Acetylcholine Receptor

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1984 Jan 1

PMID 6320162

Citations 134

Authors

J Finer-Moore

R M Stroud

Affiliations

Soon will be listed here.

Abstract

Fourier analysis of the hydrophobicities of the acetylcholine receptor subunit sequences reveals regions of amphipathic secondary structure. Prediction of a consensus secondary structure based on this analysis and on an empirical prediction method leads to a testable hypothesis about how the ion channel is formed and might function. Knowledge of the three-dimensional structure of acetylcholine receptors is consistent with features of the model proposed and provides some constraints.

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