"Pertussis Toxin Induces Tachycardia and Impairs the Increase in Blood Pressure Produced by Alpha 2-adrenergic Agonists"

Overview

Journal Life Sci

Publisher Elsevier

Specialties Biochemistry
Biology
Physiology

Date 1983 Dec 26

PMID 6319845

Citations 6

Authors

J L Boyer

C Cardenas

C Posadas

J A Garcia-Sainz

Affiliations

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Abstract

Administration of purified pertussis toxin to rats induced persistent tachycardia, (observed in conscious rats but not after pithing); as little as 0.05 microgram/100 g produced a significant effect. Pertussis toxin-treatment did not affected the pressor response produced in the pithed rats by the alpha 2-adrenergic agonist methoxamine but markedly diminished the pressor effect of the alpha 2-adrenergic agonists clonidine and azepexole. A role of adenylate cyclase inhibition in the action of postsynaptic vascular alpha 2-adrenergic receptors is suggested.

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