A Wild and an Attenuated Strain of Francisella Tularensis Differ in Susceptibility to Hypochlorous Acid: a Possible Explanation of Their Different Handling by Polymorphonuclear Leukocytes

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1984 Feb 1

PMID 6319290

Citations 19

Authors

S Lofgren

A Tarnvik

M Thore

J Carlsson

Affiliations

Soon will be listed here.

Abstract

We have previously reported that a wild strain of Francisella tularensis is much less efficiently killed by human polymorphonuclear leukocytes than is an attenuated strain. In the present study, the killing of the attenuated strain was found to be strictly oxygen dependent. The wild and the attenuated strains both induced a respiratory burst in the leukocytes. The difference between the strains in susceptibility to agents produced at the burst could be explained by a difference in susceptibility to hypochlorous acid.

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