Can Blocking the Na/K Exchange Pump Lead to a Reduction in Intracellular Sodium?

Overview

Journal Experientia

Specialty Science

Date 1983 Nov 15

PMID 6315475

Citations 3

Authors

I S Cohen

Affiliations

Soon will be listed here.

Abstract

It has been assumed that a rise in intracellular sodium should follow inhibition of the Na/K exchange pump. However, under certain conditions a reduction in intracellular sodium following pump blockage is possible. Many results postulating 'stimulation' of the Na/K exchange pump by low doses of the cardiac glycosides can be explained in this manner.

Citing Articles

Effects of stimulation and diphenylhydantoin on the intracellular sodium activity in Purkinje fibres of sheep heart.

Ellis D J Physiol. 1985; 362:331-48.

PMID: 4020690 PMC: 1192900. DOI: 10.1113/jphysiol.1985.sp015681.

Relation between Na+-K+ pump, Na+ activity and force in strophanthidin inotropy in sheep cardiac Purkinje fibres.

Abete P, Vassalle M J Physiol. 1988; 404:275-99.

PMID: 3253433 PMC: 1190826. DOI: 10.1113/jphysiol.1988.sp017290.

Dissociation between force and intracellular sodium activity with strophanthidin in isolated sheep Purkinje fibres.

Boyett M, Hart G, Levi A J Physiol. 1986; 381:311-31.

PMID: 2442352 PMC: 1182981. DOI: 10.1113/jphysiol.1986.sp016329.

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