Complete Amino Acid Sequence of Human T-cell Leukemia Virus Structural Protein P15

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1983 Oct 17

PMID 6313426

Citations 22

Authors

T D Copeland

S Oroszlan

V S Kalyanaraman

M G Sarngadharan

R C Gallo

Affiliations

Soon will be listed here.

Abstract

The complete amino acid sequence of human T-cell leukemia virus (HTLV) structural protein p15 has been determined. The intact protein and peptides generated by enzymatic digestion and acid cleavage were purified by reversed-phase liquid chromatography and subjected to semi-automated Edman degradation. HTLV p15 is a basic linear polypeptide composed of 85 amino acids with Mr 9458. The primary structure indicates that HTLV p15 is homologous to the nucleic acid binding proteins of other type-C retroviruses and especially related to bovine leukemia virus p12.

Citing Articles

Stephan Oroszlan and the Proteolytic Processing of Retroviral Proteins: Following A Pro.

Swanstrom R, Sundquist W Viruses. 2021; 13(11).

PMID: 34835024 PMC: 8621278. DOI: 10.3390/v13112218.

Retrospective on the all-in-one retroviral nucleocapsid protein.

Darlix J, de Rocquigny H, Mauffret O, Mely Y Virus Res. 2014; 193:2-15.

PMID: 24907482 PMC: 7114435. DOI: 10.1016/j.virusres.2014.05.011.

An unusually compact retrotransposon in maize.

Johns M, Babcock M, Fuerstenberg S, Fuerstenberg S, Freeling M, Simpson R Plant Mol Biol. 2013; 12(6):633-42.

PMID: 24271196 DOI: 10.1007/BF00044154.

The origin and evolution of human T-cell lymphotropic virus types I and II.

Suzuki Y, Gojobori T Virus Genes. 1998; 16(1):69-84.

PMID: 9562892 DOI: 10.1023/a:1007953826869.

Human T-cell leukemia virus type 1 protease protein expressed in Escherichia coli possesses aspartic proteinase activity.

SAIGA A, Tanaka T, Orita S, Sato A, Sato S, Hachisu T Arch Virol. 1993; 128(3-4):195-210.

PMID: 8435041 DOI: 10.1007/BF01309434.