Serodiagnosis of Viral Hepatitis A: Rise in Antibody Titre and Evaluation of Three Methods for Detecting Early and Late Antibodies

Overview

Journal Experientia

Specialty Science

Date 1983 Aug 15

PMID 6307738

Authors

C Girardet

R Peitrequin

P C Frei

Affiliations

Soon will be listed here.

Abstract

A serological investigation was made on patients with viral hepatitis A and individuals with a past history of this disease. Titration of antibody in sequential samples was found to be of no help in diagnosis. Separation of early (IgM) from late (IgG) antibodies by protein A or by 2-mercaptoethanol did not prove to be convenient for the serodiagnosis. A chromatographic separation of late and early antibody was found to be satisfactory, and equivalent to a radioimmunoassay for IgM-antibodies.

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